WormBase Tree Display for Gene: WBGene00001103

WBGene00001103 SMap: S_parent: Sequence: W09G12
  Identity: Version: 1
    Name: CGC_name: dsl-1 Person_evidence: WBPerson220
      Sequence_name: W09G12.4
      Molecular_name: W09G12.4
        W09G12.4.1
        CE18343
      Other_name: CELE_W09G12.4 Accession_evidence: NDB BX284604
      Public_name: dsl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dsl
    Allele (22)
    Strain: WBStrain00002904
      WBStrain00008055
    RNASeq_FPKM (74)
    GO_annotation: 00034014
      00034015
      00034016
      00034017
      00034018
      00108253
      00108254
      00108255
      00108256
      00108257
    Ortholog (31)
    Paralog: WBGene00002246 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001104 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001105 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001107 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001108 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001109 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00023163 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00021525 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00021513 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: dsl-1 encodes a secreted protein with a single DSL and EGF domain inseries, resembling Delta/LAG-2; DSL-1, with APX-1 and LAG-2, iscollectively required for LIN-12/Notch-mediated lateral signalling duringpostembryonic vulval development; DSL-1, when misexpressed by lag-2sequences, can rescue the larval-lethal and anchor cell phenotypes oflag-2(q420ts); dsl-1(RNAi) animals have abnormal vulvae in a geneticbackground sensitized for lateral signalling defects; dsl-1(ok810)mutants, while viable and fertile, have a 4% penetrant defect in lateralsignaling, which exceeds 13% with apx-1 and lag-2 RNAi; dsl-1 is stronglytranscribed in P6.p cells; SUR-2 regulates dsl-1 along with apx-1 andlag-2; DSL-1 belongs to a nematode-specific family of Delta/LAG-2-likeproteins that includes DSL-2, -3, -5, -6, and -7. Paper_evidence: WBPaper00006450
          Curator_confirmed: WBPerson567
          Date_last_updated: 21 Aug 2006 00:00:00
      Automated_description: Enables Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in extracellular region and membrane. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; P6.ppp; and vulval cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W09G12.4
    Corresponding_transcript: W09G12.4.1
    Associated_feature: WBsf651642
      WBsf717130
      WBsf717131
      WBsf229751
  Experimental_info: RNAi_result (14)
    Expr_pattern: Chronogram1782
      Expr2842
      Expr6863
      Expr10275
      Expr1023005
      Expr1030703
      Expr1158595
      Expr2011105
      Expr2029341
    Drives_construct: WBCnstr00000065
      WBCnstr00003420
      WBCnstr00015222
      WBCnstr00018944
    Microarray_results (19)
    Expression_cluster (129)
    Interaction: WBInteraction000003865
      WBInteraction000003868
      WBInteraction000003871
      WBInteraction000009999
      WBInteraction000030383
      WBInteraction000030384
      WBInteraction000051468
      WBInteraction000051469
      WBInteraction000051486
      WBInteraction000051487
      WBInteraction000122483
      WBInteraction000146240
      WBInteraction000165704
      WBInteraction000165948
      WBInteraction000166319
      WBInteraction000172022
      WBInteraction000178519
      WBInteraction000180316
      WBInteraction000180526
      WBInteraction000181592
      WBInteraction000190176
      WBInteraction000191186
      WBInteraction000192857
      WBInteraction000195308
      WBInteraction000195826
      WBInteraction000200807
      WBInteraction000201364
      WBInteraction000202569
      WBInteraction000203491
      WBInteraction000204223
      WBInteraction000205820
      WBInteraction000206176
      WBInteraction000211277
      WBInteraction000214620
      WBInteraction000218569
      WBInteraction000218579
      WBInteraction000220399
      WBInteraction000223053
      WBInteraction000225880
      WBInteraction000227091
      WBInteraction000228206
      WBInteraction000230168
      WBInteraction000230370
      WBInteraction000231488
      WBInteraction000232181
      WBInteraction000233312
      WBInteraction000233489
      WBInteraction000236671
      WBInteraction000237641
      WBInteraction000237922
      WBInteraction000240309
      WBInteraction000242981
      WBInteraction000245665
      WBInteraction000247750
      WBInteraction000248526
      WBInteraction000250539
      WBInteraction000250627
      WBInteraction000252674
      WBInteraction000253516
      WBInteraction000254063
      WBInteraction000257194
      WBInteraction000258436
      WBInteraction000259810
      WBInteraction000261387
      WBInteraction000261534
      WBInteraction000262116
      WBInteraction000262401
      WBInteraction000265967
      WBInteraction000266772
      WBInteraction000268257
      WBInteraction000269469
      WBInteraction000270176
      WBInteraction000270708
      WBInteraction000270745
      WBInteraction000273480
      WBInteraction000275725
      WBInteraction000275777
      WBInteraction000277291
      WBInteraction000277844
      WBInteraction000277911
      WBInteraction000281143
      WBInteraction000283909
      WBInteraction000284764
      WBInteraction000284790
      WBInteraction000289282
      WBInteraction000289930
      WBInteraction000290351
      WBInteraction000291109
      WBInteraction000291929
      WBInteraction000294092
      WBInteraction000295904
      WBInteraction000296032
      WBInteraction000296426
      WBInteraction000298281
      WBInteraction000299264
      WBInteraction000299310
      WBInteraction000300179
      WBInteraction000301860
      WBInteraction000304259
      WBInteraction000307364
      WBInteraction000308000
      WBInteraction000308131
      WBInteraction000310557
      WBInteraction000311881
      WBInteraction000315557
      WBInteraction000315833
      WBInteraction000317645
      WBInteraction000318397
      WBInteraction000318574
      WBInteraction000321224
      WBInteraction000321414
      WBInteraction000321443
      WBInteraction000321945
      WBInteraction000322034
      WBInteraction000323000
      WBInteraction000324559
      WBInteraction000325518
      WBInteraction000325827
      WBInteraction000326976
      WBInteraction000329527
      WBInteraction000330766
      WBInteraction000331254
      WBInteraction000336203
      WBInteraction000339197
      WBInteraction000342277
      WBInteraction000342327
      WBInteraction000342746
      WBInteraction000342843
      WBInteraction000343075
      WBInteraction000346215
      WBInteraction000351243
      WBInteraction000352326
      WBInteraction000355109
      WBInteraction000355516
      WBInteraction000360227
      WBInteraction000361105
      WBInteraction000362714
      WBInteraction000363416
      WBInteraction000364104
      WBInteraction000364673
      WBInteraction000367831
      WBInteraction000368845
      WBInteraction000370442
      WBInteraction000371792
      WBInteraction000372038
      WBInteraction000373152
      WBInteraction000373669
      WBInteraction000375245
      WBInteraction000376103
      WBInteraction000377332
      WBInteraction000378831
      WBInteraction000380483
      WBInteraction000385284
      WBInteraction000387210
      WBInteraction000389991
      WBInteraction000391400
      WBInteraction000391494
      WBInteraction000393304
      WBInteraction000393337
      WBInteraction000393535
      WBInteraction000393938
      WBInteraction000395443
      WBInteraction000395727
      WBInteraction000396960
      WBInteraction000397800
      WBInteraction000399284
      WBInteraction000399682
      WBInteraction000399960
      WBInteraction000406364
      WBInteraction000407105
      WBInteraction000409459
      WBInteraction000410159
      WBInteraction000410382
      WBInteraction000410555
      WBInteraction000412265
      WBInteraction000412383
      WBInteraction000416487
      WBInteraction000416867
      WBInteraction000417164
      WBInteraction000419026
      WBInteraction000426440
      WBInteraction000427402
      WBInteraction000430774
      WBInteraction000431453
      WBInteraction000433934
      WBInteraction000434525
      WBInteraction000439661
      WBInteraction000440243
      WBInteraction000441332
      WBInteraction000442936
      WBInteraction000445097
      WBInteraction000445149
      WBInteraction000445574
      WBInteraction000446081
      WBInteraction000449720
      WBInteraction000452938
      WBInteraction000454723
      WBInteraction000460047
      WBInteraction000460978
      WBInteraction000461803
      WBInteraction000540395
      WBInteraction000542960
    WBProcess: WBbiopr:00000072
  Map_info: Map: IV Position: -21.0913 Error: 0.040765
    Positive: Positive_clone: W09G12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene