WormBase Tree Display for Gene: WBGene00000991

WBGene00000991 SMap: S_parent: Sequence: M03A8
  Identity: Version: 1
    Name: CGC_name: dhs-28 Person_evidence: WBPerson651
      Sequence_name: M03A8.1
      Molecular_name: M03A8.1
        M03A8.1.1
        CE04770
      Other_name: CELE_M03A8.1 Accession_evidence: NDB BX284606
      Public_name: dhs-28
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dhs
    Allele (44)
    Strain: WBStrain00035626
      WBStrain00040189
      WBStrain00050737
      WBStrain00050738
      WBStrain00050736
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (37)
    Paralog (38)
    Structured_description: Concise_description: dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. Paper_evidence: WBPaper00004424
          Curator_confirmed: WBPerson48
            WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Involved in several processes, including carbohydrate derivative metabolic process; dauer entry; and positive regulation of developmental process. Located in peroxisome. Expressed in hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00035972
          Curator_confirmed: WBPerson38202
          Date_last_updated: 29 Jun 2018 00:00:00
    Potential_model: DOID:13366 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
      DOID:0090031 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
      DOID:0050857 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
  Models_disease_asserted: WBDOannot00000570
    WBDOannot00000571
  Molecular_info: Corresponding_CDS: M03A8.1
    Corresponding_transcript: M03A8.1.1
    Other_sequence (107)
    Associated_feature: WBsf648263
      WBsf648264
      WBsf662918
      WBsf235872
      WBsf235873
  Experimental_info: RNAi_result: WBRNAi00108444 Inferred_automatically: RNAi_primary
      WBRNAi00008998 Inferred_automatically: RNAi_primary
      WBRNAi00050847 Inferred_automatically: RNAi_primary
      WBRNAi00034393 Inferred_automatically: RNAi_primary
      WBRNAi00025981 Inferred_automatically: RNAi_primary
      WBRNAi00092604 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8991
      Expr1020554
      Expr1030616
      Expr1154542
      Expr2010912
      Expr2029151
    Drives_construct: WBCnstr00013659
      WBCnstr00037154
    Construct_product: WBCnstr00013659
      WBCnstr00023002
      WBCnstr00037154
    Antibody: WBAntibody00001955
      WBAntibody00002918
    Microarray_results (27)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00028802:intestine_unique
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00035073:mitochondria_protein
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046303:P.aeruginosa_upregulated_protein
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050448:KGB-1-induced
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_HighSalt
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053094:adr-2(ok735)_neuron_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:OP50_vs_PY79_downregulated_PY79
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056284:ints-4(RNAi)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00056997:NMAD-1_interacting
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061221:H4K8ac_interacting
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:Intestine
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061527:C24A3.4_16071-ech-8
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064257:UNG-1_interacting
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:33_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_4
      cgc4489_group_8
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_12
      WBPaper00025032:cluster_16
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045673:colistin_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(83_min)
      [cgc6390]:Cluster_C
    Interaction (99)
  Map_info: Map: X Position: -2.40245 Error: 0.010942
    Positive: Positive_clone: M03A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4258
        4343
        5031
    Pseudo_map_position
  Reference (31)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene