WormBase Tree Display for Gene: WBGene00000898
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WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info (12) | |||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Nov 2022 00:00:00 | ||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||
Potential_model (37) | |||||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||
WBPaper00025083 | |||||||
WBPaper00031384 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||
Models_disease_in_annotation | WBDOannot00000339 | ||||||
Models_disease_asserted | WBDOannot00001356 | ||||||
Molecular_info | Corresponding_CDS | Y55D5A.5a | |||||
Y55D5A.5c | |||||||
Y55D5A.5d | |||||||
Y55D5A.5e | |||||||
Y55D5A.5f | |||||||
Y55D5A.5g | |||||||
Corresponding_CDS_history | Y55D5A.5:wp187 | ||||||
Y55D5A.5a:wp229 | |||||||
Y55D5A.5b:wp229 | |||||||
Y55D5A.5b:wp247 | |||||||
Corresponding_transcript | Y55D5A.5b | ||||||
Y55D5A.5a.1 | |||||||
Y55D5A.5c.1 | |||||||
Y55D5A.5d.1 | |||||||
Y55D5A.5e.1 | |||||||
Y55D5A.5f.1 | |||||||
Y55D5A.5g.1 | |||||||
Other_sequence (112) | |||||||
Associated_feature (24) | |||||||
Experimental_info (11) | |||||||
Map_info | Map | III | Position | -8.03413 | Error | 0.111365 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf11 | |||||
Positive_clone | C44B11 | ||||||
H05C05 | |||||||
Y55D5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Outside_rearr | tDf9 | |||||
Mapping_data | 2_point | 273 | |||||
411 | |||||||
412 | |||||||
7053 | |||||||
Multi_point (23) | |||||||
Pos_neg_data (12) | |||||||
Reference (1726) | |||||||
Picture | WBPicture0000013078 | ||||||
WBPicture0000013087 | |||||||
Method | Gene |