WormBase Tree Display for Gene: WBGene00000898
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| WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | daf-2 | Person_evidence | WBPerson521 | |||||
| Sequence_name | Y55D5A.5 | ||||||||
| Molecular_name (19) | |||||||||
| Other_name | CELE_Y55D5A.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | daf-2 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2022 00:00:00 | ||||||||
| DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
| Potential_model (37) | |||||||||
| Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||||
| WBPaper00025083 | |||||||||
| WBPaper00031384 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
| In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||||
| Models_disease_in_annotation | WBDOannot00000339 | ||||||||
| Models_disease_asserted | WBDOannot00001356 | ||||||||
| Molecular_info | Corresponding_CDS | Y55D5A.5a | |||||||
| Y55D5A.5c | |||||||||
| Y55D5A.5d | |||||||||
| Y55D5A.5e | |||||||||
| Y55D5A.5f | |||||||||
| Y55D5A.5g | |||||||||
| Corresponding_CDS_history | Y55D5A.5:wp187 | ||||||||
| Y55D5A.5a:wp229 | |||||||||
| Y55D5A.5b:wp229 | |||||||||
| Y55D5A.5b:wp247 | |||||||||
| Corresponding_transcript | Y55D5A.5b | ||||||||
| Y55D5A.5a.1 | |||||||||
| Y55D5A.5c.1 | |||||||||
| Y55D5A.5d.1 | |||||||||
| Y55D5A.5e.1 | |||||||||
| Y55D5A.5f.1 | |||||||||
| Y55D5A.5g.1 | |||||||||
| Other_sequence | JI237318.1 | ||||||||
| JI460661.1 | |||||||||
| JI460782.1 | |||||||||
| Dviv_isotig32613 | |||||||||
| JI225485.1 | |||||||||
| FG588429.1 | |||||||||
| TS01021 | |||||||||
| JI164345.1 | |||||||||
| GW410969.1 | |||||||||
| GW410933.1 | |||||||||
| MCC00359_1 | |||||||||
| FG586878.1 | |||||||||
| FC818202.1 | |||||||||
| FG587857.1 | |||||||||
| ASC20077_1 | |||||||||
| AI444866.1 | |||||||||
| FG586943.1 | |||||||||
| PP01165 | |||||||||
| JI213932.1 | |||||||||
| DW718573.1 | |||||||||
| FG352215.1 | |||||||||
| FG347841.1 | |||||||||
| JI164390.1 | |||||||||
| TSC01028_1 | |||||||||
| TSC02510_1 | |||||||||
| OVC04036_1 | |||||||||
| MJ00249 | |||||||||
| TSC10854_1 | |||||||||
| TSC03411_1 | |||||||||
| FG586220.1 | |||||||||
| EX538544.1 | |||||||||
| AS06201 | |||||||||
| FG347989.1 | |||||||||
| JI463509.1 | |||||||||
| Dviv_isotig27979 | |||||||||
| TS00523 | |||||||||
| CV200966.1 | |||||||||
| JI247992.1 | |||||||||
| FG351045.1 | |||||||||
| Dviv_isotig31481 | |||||||||
| FG349482.1 | |||||||||
| FG352798.1 | |||||||||
| TSC09797_1 | |||||||||
| TS02403 | |||||||||
| AS17556 | |||||||||
| MAC02439_1 | |||||||||
| JI165945.1 | |||||||||
| FG585129.1 | |||||||||
| PPC01096_1 | |||||||||
| JI462906.1 | |||||||||
| JI463196.1 | |||||||||
| Dviv_contig33821 | |||||||||
| FG580350.1 | |||||||||
| MC01673 | |||||||||
| FG352161.1 | |||||||||
| FG351461.1 | |||||||||
| MC03832 | |||||||||
| FG580085.1 | |||||||||
| EX563902.1 | |||||||||
| TSC01031_1 | |||||||||
| FG587221.1 | |||||||||
| MH08265 | |||||||||
| FG348325.1 | |||||||||
| Oden_isotig27208 | |||||||||
| Dviv_isotig22935 | |||||||||
| JI237473.1 | |||||||||
| FG353834.1 | |||||||||
| JI247889.1 | |||||||||
| FG585478.1 | |||||||||
| TMC04635_1 | |||||||||
| FG585066.1 | |||||||||
| PSC03323_1 | |||||||||
| BMC08388_1 | |||||||||
| FG352162.1 | |||||||||
| TS00880 | |||||||||
| AS06502 | |||||||||
| FG585852.1 | |||||||||
| JI233811.1 | |||||||||
| JI244268.1 | |||||||||
| FG582133.1 | |||||||||
| FG355363.1 | |||||||||
| ES569665.1 | |||||||||
| SRC01234_1 | |||||||||
| TSC07906_1 | |||||||||
| FG347532.1 | |||||||||
| DN152658.1 | |||||||||
| TSC00032_1 | |||||||||
| ES566643.1 | |||||||||
| MHC05309_1 | |||||||||
| ACC14364_1 | |||||||||
| PSC03250_1 | |||||||||
| FG584848.1 | |||||||||
| ES561086.1 | |||||||||
| JI224031.1 | |||||||||
| TSC09099_1 | |||||||||
| EX564073.1 | |||||||||
| Tcir_isotig30532 | |||||||||
| FC812547.1 | |||||||||
| CV198761.1 | |||||||||
| JI182592.1 | |||||||||
| FG581255.1 | |||||||||
| JI248593.1 | |||||||||
| GP01589 | |||||||||
| FG588689.1 | |||||||||
| AS17633 | |||||||||
| MCC02025_1 | |||||||||
| CV200947.1 | |||||||||
| TSC01374_1 | |||||||||
| TM00309 | |||||||||
| FG350944.1 | |||||||||
| JI182489.1 | |||||||||
| FG349375.1 | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | III | Position | -8.03413 | Error | 0.111365 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf11 | |||||||
| Positive_clone | C44B11 | ||||||||
| H05C05 | |||||||||
| Y55D5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | tDf9 | |||||||
| Mapping_data | 2_point | 273 | |||||||
| 411 | |||||||||
| 412 | |||||||||
| 7053 | |||||||||
| Multi_point (23) | |||||||||
| Pos_neg_data (12) | |||||||||
| Reference (1726) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| WBPicture0000013087 | |||||||||
| Method | Gene |
