| WBGene00000857 | SMap | S_parent | Sequence | K10B4 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cwn-1 | Person_evidence | WBPerson1157 |
| | | Sequence_name | K10B4.6 |
| | | Molecular_name | K10B4.6a |
| | | | K10B4.6a.1 |
| | | | CE12072 |
| | | | K10B4.6b |
| | | Other_name | Wnt-1 | Accession_evidence | EMBL | X72942 |
| | | | | | | X72941 |
| | | | CELE_K10B4.6 | Accession_evidence | NDB | BX284602 |
| | | Public_name | cwn-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cwn |
| | Allele (39) |
| | Legacy_information | [Shivakumar S, Jongeward G] early embryonic arrest. psoralen screen for lethals rescued by transgene including R180. encodes CeWnt1, a C. elegans wnt homolog. |
| | | [C.elegansII] mu109 : embryonic lethal, early arrest as disorganized embryo at 2-3 fold stage; allele obtained by psoralen screen for lethals rescued by cwn-1 transgene. OA1: mu110.Cloned: 1.4 kb transcript, transspliced; most abundant in embryo; encodes 372 aa Wnt homolog[Shackleford et al. 1993; CF] |
| | Strain (21) |
| | RNASeq_FPKM (74) |
| | GO_annotation (56) |
| | Ortholog (41) |
| | Paralog | WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000858 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | cwn-1 encodes one of five C. elegans Wnt signaling ligands; during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages. | Paper_evidence | WBPaper00001170 |
| | | | | | WBPaper00001743 |
| | | | | | WBPaper00025032 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 27 Apr 2009 00:00:00 |
| | | Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in extracellular space. Expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism and endometrial carcinoma. Is an ortholog of human WNT4 (Wnt family member 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) |
| | | DOID:0111526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) |
| Molecular_info | Corresponding_CDS | K10B4.6a |
| | Corresponding_CDS_history | K10B4.6b:wp247 |
| | Corresponding_transcript | K10B4.6b |
| | | K10B4.6a.1 |
| | Other_sequence (37) |
| | Associated_feature | WBsf649804 |
| | | WBsf986332 |
| | | WBsf1011348 |
| | | WBsf222564 |
| | | WBsf222565 |
| | | WBsf222566 |
| | | WBsf222567 |
| Experimental_info | RNAi_result (30) |
| | Expr_pattern (20) |
| | Drives_construct (20) |
| | Construct_product (15) |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00031040:Cluster_1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035197:fer-1_downregulated |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037946:MAB-5_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_downregulated |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:M_cell |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:met-1(bn200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:1_1 |
| | | WBPaper00065841:7_4 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:38_0 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:38_3 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:69_0 |
| | | WBPaper00065841:75_0 |
| | | WBPaper00065841:102_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065841:145_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_60 |
| | | WBPaper00025032:PAL-1_target_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotype_environment_interaction |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (67) |
| | WBProcess | WBbiopr:00000017 |
| | | WBbiopr:00000023 |
| | | WBbiopr:00000073 |
| Map_info | Map | II | Position | -15.9676 | Error | 0.013997 |
| | Positive | Positive_clone | K10B4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | R180 |
| | Mapping_data | Multi_point | 4244 |
| | Pseudo_map_position |
| Reference (89) |
| Remark | replaces int-12, pcr clone isolated by Sasha Kamb. the accession numbers for these genes X72941 cwn-1 mRNA X72942 cwn-1 gene (introns included) |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
