WormBase Tree Display for Gene: WBGene00000845

WBGene00000845 Evidence: Person_evidence: WBPerson170
  SMap: S_parent: Sequence: C02C2
  Identity: Version: 1
    Name: CGC_name: cup-4 Person_evidence: WBPerson170
      Sequence_name: C02C2.3
      Molecular_name: C02C2.3
        C02C2.3.1
        CE30416
      Other_name: CELE_C02C2.3 Accession_evidence: NDB BX284603
      Public_name: cup-4
    DB_info: Database (9)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cup
    Allele (34)
    Strain: WBStrain00031661
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog: WBGene00064099 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00033246 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00163523 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00108406 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00120900 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00268467 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6036 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8381 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8017 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7454 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3142 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18239 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7643 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6200 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g3390 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1046 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00300.g8791 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-cup-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold615.g5984 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_05060.g34304 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07992 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_24337 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009145 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04563 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g22206 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30043200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8240 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00246301 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00262473 Strongyloides ratti From_analysis: WormBase-Compara
    Paralog (100)
    Structured_description: Concise_description: cup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles. Paper_evidence: WBPaper00004883
            WBPaper00006324
            WBPaper00025238
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 01 Sep 2010 00:00:00
      Automated_description: Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C02C2.3
    Corresponding_transcript: C02C2.3.1
    Other_sequence: JO468316.1
      JI169898.1
      Oden_isotig23439
    Associated_feature: WBsf645364
      WBsf225290
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr3280
      Expr16469
      Expr1011461
      Expr1030524
      Expr1143520
      Expr1200314
      Expr2010596
      Expr2028836
    Drives_construct: WBCnstr00005671
      WBCnstr00005672
      WBCnstr00011282
      WBCnstr00037250
    Construct_product: WBCnstr00007433
      WBCnstr00011282
      WBCnstr00037250
    Microarray_results (20)
    Expression_cluster (119)
    Interaction: WBInteraction000051699
      WBInteraction000390325
      WBInteraction000421321
      WBInteraction000585701
  Map_info: Map: III Position: -0.533135 Error: 0.003482
    Positive: Positive_clone: C02C2 Inferred_automatically: From sequence, transcript, pseudogene data
        pJF148 Person_evidence: WBPerson170
    Mapping_data: Multi_point: 3952
        5055
  Reference (13)
  Remark: pJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAi Person_evidence: WBPerson170
  Method: Gene