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WormBase Tree Display for Gene: WBGene00000845

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Name Class

WBGene00000845EvidencePerson_evidenceWBPerson170
SMapS_parentSequenceC02C2
IdentityVersion1
NameCGC_namecup-4Person_evidenceWBPerson170
Sequence_nameC02C2.3
Molecular_nameC02C2.3
C02C2.3.1
CE30416
Other_nameCELE_C02C2.3Accession_evidenceNDBBX284603
Public_namecup-4
DB_infoDatabaseAceViewgene3I957
WormQTLgeneWBGene00000845
WormFluxgeneWBGene00000845
NDBlocus_tagCELE_C02C2.3
PanthergeneCAEEL|WormBase=WBGene00000845|UniProtKB=P34271
familyPTHR18945
NCBIgene176104
RefSeqproteinNM_066309.6
SwissProtUniProtAccP34271
UniProt_GCRPUniProtAccP34271
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcup
Allele (34)
StrainWBStrain00031661
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (29)
Paralog (100)
Structured_descriptionConcise_descriptioncup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles.Paper_evidenceWBPaper00004883
WBPaper00006324
WBPaper00025238
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated01 Sep 2010 00:00:00
Automated_descriptionPredicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC02C2.3
Corresponding_transcriptC02C2.3.1
Other_sequenceJO468316.1
JI169898.1
Oden_isotig23439
Associated_featureWBsf645364
WBsf225290
Experimental_infoRNAi_result (14)
Expr_patternExpr3280
Expr16469
Expr1011461
Expr1030524
Expr1143520
Expr1200314
Expr2010596
Expr2028836
Drives_constructWBCnstr00005671
WBCnstr00005672
WBCnstr00011282
WBCnstr00037250
Construct_productWBCnstr00007433
WBCnstr00011282
WBCnstr00037250
Microarray_results (20)
Expression_clusterWBPaper00024505:pharyngeal_enriched
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:coelomocytes_CoreEnriched
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:coelomocytes_larva_enriched
WBPaper00037950:coelomocytes_larva_SelectivelyEnriched
WBPaper00044426:rotenone_5day_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046121:mesoderm_unique
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050015:ifg-1(RNAi)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058678:DAF-12_upregulated_PVD
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(overexpression)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060909:atfs-1(et18)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Coelomocyte
WBPaper00061340:hmc_and_homolog
WBPaper00061341:28C_24h_upregulated
WBPaper00061527:cup-4_19385-ZC116.3_20579
WBPaper00061651:Coelomocyte_enriched
WBPaper00061692:acivicin_upregulated
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065623:31
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_0
WBPaper00065841:12_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4386_cluster_6_6
cgc4489_group_4
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Photorhabdus_luminescens_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032062:age_regulated_genes
WBPaper00034757:up_by_oxidative_stress
WBPaper00036286:Pattern_I
WBPaper00038462:aging_downregulated
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048989:N2_rapamycin_upregulated
InteractionWBInteraction000051699
WBInteraction000390325
WBInteraction000421321
WBInteraction000585701
Map_infoMapIIIPosition-0.533135Error0.003482
PositivePositive_cloneC02C2Inferred_automaticallyFrom sequence, transcript, pseudogene data
pJF148Person_evidenceWBPerson170
Mapping_dataMulti_point3952
5055
Reference (13)
RemarkpJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAiPerson_evidenceWBPerson170
MethodGene