WormBase Tree Display for Gene: WBGene00000832

WBGene00000832 SMap: S_parent: Sequence: Y23H5A
  Identity: Version: 1
    Name: CGC_name: ctn-1 Person_evidence: WBPerson481
      Sequence_name: Y23H5A.5
      Molecular_name (12)
      Other_name: Y23H5A.c Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y23H5A.5 Accession_evidence: NDB BX284601
      Public_name: ctn-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ctn
    Allele: WBVar00278361 Inferred_automatically: From strain object: VC2457
      WBVar02147481
      WBVar00620986
      WBVar00620987
      WBVar00620988
      WBVar00620989
      WBVar00620990
      WBVar02106062
      WBVar00620991
      WBVar00235786
      WBVar02106063
      WBVar00620992
      WBVar00620993
      WBVar02080489
      WBVar00620994
      WBVar00620995
      WBVar00620996
      WBVar00620997
      WBVar00620998
      WBVar00620999
      WBVar00621000
      WBVar00621001
      WBVar00621002
      WBVar02097243
      WBVar00621003
      WBVar00621004
      WBVar02097244
      WBVar00621005
      WBVar00621006
      WBVar00621007
      WBVar02055441
      WBVar02088600
      WBVar00621008
      WBVar00621009
      WBVar00621010
      WBVar00621011
      WBVar00621012
      WBVar00621013
      WBVar01500096
      WBVar00621014
      WBVar02141109
      WBVar00621015
      WBVar00621016
      WBVar00621017
      WBVar00621018
      WBVar00621019
      WBVar00621020
      WBVar00621021
      WBVar01402920
      WBVar01956388
      WBVar00621022
      WBVar00621023
      WBVar00621024
      WBVar00621025
      WBVar00621026
      WBVar00150861
      WBVar00621027
      WBVar00150862
      WBVar00150863
      WBVar00328790
      WBVar00621028
      WBVar00621029
      WBVar00328791
      WBVar00150866
      WBVar00621030
      WBVar00328792
      WBVar00150867
      WBVar00621031
      WBVar00150870
      WBVar00328793
      WBVar00328794
      WBVar00621032
      WBVar00328795
      WBVar00621033
      WBVar00328796
      WBVar00621034
      WBVar00328797
      WBVar00621035
      WBVar00621036
      WBVar00328798
      WBVar02076996
      WBVar00621037
      WBVar01846093
      WBVar00328799
      WBVar00328800
      WBVar00621038
      WBVar02049337
      WBVar00621039
      WBVar00328801
      WBVar00328802
      WBVar00621040
      WBVar00597710
      WBVar00621041
      WBVar00328803
      WBVar00621042
      WBVar00328804
      WBVar00621043
      WBVar00328805
      WBVar00621044
      WBVar00328806
      WBVar00621045
      WBVar00328807
      WBVar01640663
      WBVar00328808
      WBVar00233265
      WBVar01640664
      WBVar00621046
      WBVar01500313
      WBVar00328809
      WBVar01640665
      WBVar00621047
      WBVar01500314
      WBVar00328810
      WBVar01640666
      WBVar01640667
      WBVar00328811
      WBVar01500315
      WBVar01640668
      WBVar00328812
      WBVar01500316
      WBVar01412711
      WBVar00328813
      WBVar00328814
      WBVar01914447
      WBVar01391608
      WBVar01391609
      WBVar01914448
      WBVar00328815
      WBVar00240420
      WBVar00328816
      WBVar01914449
      WBVar01889792
      WBVar00328817
      WBVar01914450
      WBVar02144145
      WBVar00328818
      WBVar00328819
      WBVar00328820
      WBVar01493883
      WBVar00328821
      WBVar00328822
      WBVar00328823
      WBVar00328824
      WBVar00328825
      WBVar00328826
      WBVar02001681
      WBVar02001682
      WBVar00328827
      WBVar00328828
      WBVar01662627
      WBVar02001683
      WBVar02001684
      WBVar01662628
      WBVar02001685
      WBVar01662629
      WBVar02079080
      WBVar01662630
      WBVar02001686
      WBVar01662631
      WBVar02001687
      WBVar01662632
      WBVar01662633
      WBVar01499786
      WBVar01662634
      WBVar01662635
      WBVar01662636
      WBVar02006252
      WBVar01662637
      WBVar01662638
      WBVar01662639
      WBVar01998802
      WBVar01662640
      WBVar01662641
      WBVar01662642
      WBVar01662643
      WBVar01662644
      WBVar02125178
      WBVar01662645
      WBVar00097159
      WBVar01931764
      WBVar01662646
      WBVar01662647
      WBVar00097161
      WBVar01279881
      WBVar01499985
      WBVar01662648
      WBVar01662649
      WBVar01662650
      WBVar01499252
      WBVar01498892
      WBVar01244029
      WBVar00535040
      WBVar02047924
      WBVar01496336
      WBVar00257393
      WBVar00024906
      WBVar01993037
      WBVar02028313
      WBVar00024911
      WBVar02028314
      WBVar01993038
      WBVar02028315
      WBVar02028316
      WBVar00024916
      WBVar00024921
      WBVar00024926
      WBVar01420176
      WBVar01420180
      WBVar01420184
      WBVar00024931
      WBVar01420185
      WBVar00024936
      WBVar00024941
      WBVar02126647
      WBVar02126648
      WBVar00024946
      WBVar00620967
      WBVar00620968
      WBVar00024951
      WBVar00620969
      WBVar00620970
      WBVar00620971
      WBVar00620972
      WBVar00024956
      WBVar00620973
      WBVar00296540
      WBVar00620974
      WBVar00296541
      WBVar00620975
      WBVar00296542
      WBVar00620976
      WBVar00296543
      WBVar00620977
      WBVar00296544
      WBVar00620978
      WBVar00620979
      WBVar00620980
      WBVar01489942
      WBVar00620981
      WBVar00296796
      WBVar00296797
      WBVar00620982
      WBVar00620983
      WBVar00620984
      WBVar00620985
    Strain: WBStrain00037343
    RNASeq_FPKM (74)
    GO_annotation: 00021143
      00021144
      00021145
      00021146
      00021147
      00021148
      00107861
      00107862
      00107863
      00107864
    Ortholog (35)
    Paralog: WBGene00000942 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00001978 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
    Structured_description: Concise_description: ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; CTN-1 physically interacts in vivo with DYB-1/dystrobrevin; a ctn-1::GFP fusion is expressed in body wall, vulval, and anal muscles; in body wall muscles, CTN-1::GFP localizes to the plasma membranes near dense bodies. Paper_evidence: WBPaper00011358
            WBPaper00041089
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 02 Aug 2012 00:00:00
      Automated_description: Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Expressed in body wall musculature; non-striated muscle; and somatic nervous system. Used to study Duchenne muscular dystrophy. Is an ortholog of human CTNNAL1 (catenin alpha like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:11723 Homo sapiens Paper_evidence: WBPaper00037625
          Accession_evidence: OMIM 310200
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 May 2017 00:00:00
    Disease_relevance: Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; a number of transmembrane and peripheral membrane proteins interact with dystrophin to form the dystrophin-associated protein complex (DAPC); defects in components of the DAPC are associated with a variety of pathological conditions, including muscular dystrophy, cardiomyopathy, myoclonic dystonia, and vasospasm; in C. elegans, the DAPC localizes near dense bodies, structures that are analogous to muscle costameres; ctn-1, an ortholog of alpha catulin (catenin-like protein), interacts with dyb-1/dystrobrevin, and this interaction is required for the normal localization of the DAPC as well as for the slo-1 voltage- and calcium-activated potassium (BK) channel, in C. elegans muscle; in the dystrophic mdx mice, there is compensatory increase of alpha-catulin expression in the skeletal muscle where the DAPC is disassembled, and the mechanical link between the muscle costamere and the sarcolemma is lost. Homo sapiens Paper_evidence: WBPaper00037625
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 May 2017 00:00:00
  Models_disease_asserted: WBDOannot00000293
  Molecular_info: Corresponding_CDS: Y23H5A.5a
      Y23H5A.5c
      Y23H5A.5d
    Corresponding_CDS_history: Y23H5A.5a:wp274
      Y23H5A.5b:wp274
      Y23H5A.5c:wp228
      Y23H5A.5d:wp210
      Y23H5A.5d:wp228
    Corresponding_transcript: Y23H5A.5e
      Y23H5A.5a.1
      Y23H5A.5c.1
      Y23H5A.5d.1
      Y23H5A.5d.2
      Y23H5A.5d.3
    Other_sequence (47)
    Associated_feature: WBsf982915
      WBsf982916
      WBsf1009363
      WBsf217315
      WBsf217316
  Experimental_info: RNAi_result: WBRNAi00002350 Inferred_automatically: RNAi_primary
      WBRNAi00055702 Inferred_automatically: RNAi_primary
      WBRNAi00055701 Inferred_automatically: RNAi_primary
      WBRNAi00116607 Inferred_automatically: RNAi_primary
      WBRNAi00004565 Inferred_automatically: RNAi_primary
      WBRNAi00022472 Inferred_automatically: RNAi_primary
      WBRNAi00036720 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00008299
      WBCnstr00008300
      WBCnstr00013721
      WBCnstr00013723
      WBCnstr00018330
      WBCnstr00037258
    Construct_product: WBCnstr00008299
      WBCnstr00008300
      WBCnstr00008301
      WBCnstr00008302
      WBCnstr00013723
      WBCnstr00013724
      WBCnstr00018330
      WBCnstr00020433
      WBCnstr00037258
    Microarray_results (51)
    Expression_cluster (177)
    Interaction (29)
  Map_info: Map: I Position: -8.18787 Error: 0.026165
    Positive: Positive_clone: Y23H5A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00011358
    WBPaper00036762
    WBPaper00037625
    WBPaper00038491
    WBPaper00039233
    WBPaper00041089
    WBPaper00043421
    WBPaper00046703
    WBPaper00055090
    WBPaper00065040
  Remark: Sequence connection from [Broadbent ID], 02/06/12 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene