WormBase Tree Display for Gene: WBGene00000792

WBGene00000792 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F11C7
  Identity: Version: 1
    Name: CGC_name: crb-1
      Sequence_name: F11C7.4
      Molecular_name: F11C7.4
        F11C7.4.1
        CE07053
      Other_name: CELE_F11C7.4 Accession_evidence: NDB BX284606
      Public_name: crb-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crb
    Allele (174)
    Strain: WBStrain00031720
    RNASeq_FPKM (74)
    GO_annotation: 00064516
      00064517
      00064518
      00064519
      00064520
      00064521
      00064522
      00064523
      00064524
      00107801
    Ortholog (37)
    Paralog: WBGene00001609 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00003001 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00008194 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012134 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013118 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018547 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018607 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: crb-1 encodes a transmembrane protein with EGF-like and laminin repeats homologous to Drosophila CRUMBS; crb-1 appears to function redundantly with let-413 to effect epithelial polarization; CRB-1 localizes to cell junctions of non-cuticular epithelia, such as the intestine and the pharynx, near the apical plasma membrane. Paper_evidence: WBPaper00004510
            WBPaper00006400
            WBPaper00032981
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 18 Dec 2009 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical part of cell and cytoplasm. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in eye disease (multiple); focal segmental glomerulosclerosis 9; and ventriculomegaly - cystic kidney disease. Is an ortholog of human CRB1 (crumbs cell polarity complex component 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050572 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
      DOID:0110079 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
      DOID:0111625 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18688)
      DOID:14791 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
      DOID:0111541 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
      DOID:0111134 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18688)
      DOID:10584 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
      DOID:0110358 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2343)
  Molecular_info: Corresponding_CDS: F11C7.4
    Corresponding_transcript: F11C7.4.1
    Other_sequence: Dviv_isotig26072
      ES672262.1
      Acan_isotig02259
      Tcol_isotig16701
      GP02701
      MJ03522
    Associated_feature (17)
  Experimental_info: RNAi_result: WBRNAi00068188 Inferred_automatically: RNAi_primary
      WBRNAi00063488 Inferred_automatically: RNAi_primary
      WBRNAi00089870 Inferred_automatically: RNAi_primary
      WBRNAi00089983 Inferred_automatically: RNAi_primary
      WBRNAi00044372 Inferred_automatically: RNAi_primary
      WBRNAi00013121 Inferred_automatically: RNAi_primary
      WBRNAi00090142 Inferred_automatically: RNAi_primary
      WBRNAi00090301 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr803
      Expr1021933
      Expr1030491
      Expr1148315
      Expr2010525
      Expr2028765
    Drives_construct: WBCnstr00037273
    Construct_product: WBCnstr00037273
    Antibody: WBAntibody00000341
    Microarray_results (21)
    Expression_cluster (146)
    Interaction (234)
  Map_info: Map: X Position: 24.0907 Error: 0.000387
    Positive: Positive_clone: F11C7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4748
    Pseudo_map_position
  Reference (19)
  Remark: Sequence connection from [Bossinger O]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene