WormBase Tree Display for Gene: WBGene00000558

WBGene00000558 Evidence: Person_evidence: WBPerson168
  SMap: S_parent: Sequence: R09B5
  Identity: Version: 1
    Name: CGC_name: cnc-4 Person_evidence: WBPerson168
      Sequence_name: R09B5.9
      Molecular_name: R09B5.9
        R09B5.9.1
        CE12634
      Other_name: CELE_R09B5.9 Accession_evidence: NDB BX284605
      Public_name: cnc-4
    DB_info: Database: AceView gene 5B925
        WormQTL gene WBGene00000558
        WormFlux gene WBGene00000558
        NDB locus_tag CELE_R09B5.9
        Panther gene CAEEL|WormBase=WBGene00000558|UniProtKB=O44613
          family PTHR22552
        NCBI gene 178635
        RefSeq protein NM_071015.7
        TrEMBL UniProtAcc O44613
        UniProt_GCRP UniProtAcc O44613
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cnc
    Allele (20)
    RNASeq_FPKM (74)
    GO_annotation: 00032947
      00032948
      00032949
    Ortholog (6)
    Structured_description: Concise_description: cnc-4 encodes one of eleven C. elegans caenacin peptides; cnc-4 expression is strongly induced after infection by the fungus Drechmeria coniospora, suggesting that it functions as a secreted antimicrobial peptide in the innate immune response. Paper_evidence: WBPaper00006488
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Jan 2010 00:00:00
      Automated_description: Involved in defense response to fungus and innate immune response. Predicted to be located in membrane. Expressed in hypodermis; intestine; and seam cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R09B5.9
    Corresponding_transcript: R09B5.9.1
    Other_sequence (15)
    Associated_feature: WBsf646663
      WBsf231407
      WBsf231408
  Experimental_info: RNAi_result: WBRNAi00051603 Inferred_automatically: RNAi_primary
      WBRNAi00034775 Inferred_automatically: RNAi_primary
      WBRNAi00017635 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8216
      Expr10690
      Expr1025430
      Expr1030337
      Expr1155277
      Expr2010265
      Expr2028507
    Drives_construct: WBCnstr00017463
      WBCnstr00037453
    Construct_product: WBCnstr00037453
    Microarray_results (17)
    Expression_cluster: WBPaper00025192:hda-1(RNAi)_upregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00033070:Elbe_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037624:ets-4(ok165)_downregulated
      WBPaper00037849:sam-10(js94)_upregulated
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00042034:NO_upregulated_N2
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045971:tunicamycin_upregulated_control
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046024:sleep_upregulated_oscillating
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050234:lin-28(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050743:elli-1(sam-3)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_upregulated
      WBPaper00053140:IncreasingResponse_20nmAgCit
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:NMD(-)_downregulated_SMD-2_non-binding_ClassIV
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00053657:N2_M.humicola-infection_24hr
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053737:Anatase-TiO2-Nanoparticles_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054191:H3.3(null)_embryo_upregulated
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054796:cav-1(RNAi)_downregulated
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059373:stt-3(RNAi)_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061340:Seam_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:ZK970.7-nlp-29
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061590:CGP37157_downregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062305:P.brevicompactum_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062587:lsl-1(ljm1)_upregulated
      WBPaper00062587:lsl-1(tm4769)_upregulated
      WBPaper00062590:Aging_upregulated_body-wall-muscle
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064473:ets-4(rrr16)_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065043:dcap-1(tm3163)_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected
      WBPaper00065272:dhgd-1(tm6671)_upregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:Lb.rhamnosus_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065759:dot-1.1(knu339)_upregulated
      WBPaper00065823:pmk-1(km25)_downregulated
      WBPaper00065841:0_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_upregulated_old-1(ok1273)
      WBPaper00066004:tdp-1(csb38)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4386_cluster_2_4
      cgc4489_group_12
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026952:class_E
      WBPaper00028474:dys-1_downregulated
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031184:acrylamide_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:FedUp
      WBPaper00034661:AgNPs_upregulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035429:UVC_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_F
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037695:WC_5-day
      WBPaper00038304:octr-1_regulated
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042258:DA1877_upregulated_YoungAdult
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044535:male_upregulated
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00049311:sAg-MNP_regulated
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00050650:mBmkTX_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_AdultDay2
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:male_soma-enriched
    Interaction: WBInteraction000364416
      WBInteraction000503904
      WBInteraction000504872
      WBInteraction000504873
      WBInteraction000504951
      WBInteraction000543093
      WBInteraction000543094
      WBInteraction000543095
  Map_info: Map: V Position: -18.9242 Error: 0.001753
    Positive: Positive_clone: R09B5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene