WormBase Tree Display for Gene: WBGene00000535

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WBGene00000535	SMap	S_parent	Sequence	K08B4
	Identity	Version	2
		Name	CGC_name	cpi-1	Paper_evidence	WBPaper00026724
						WBPaper00005846
						WBPaper00024997
					Person_evidence	WBPerson4368
						WBPerson390
			Sequence_name	K08B4.6
			Molecular_name	K08B4.6
				K08B4.6.1
				CE18035
			Other_name	cli-2
				CELE_K08B4.6	Accession_evidence	NDB	BX284604
			Public_name	cpi-1
		DB_info	Database	AceView	gene	4G858
				WormQTL	gene	WBGene00000535
				WormFlux	gene	WBGene00000535
				NDB	locus_tag	CELE_K08B4.6
				Panther	gene	CAEEL\|WormBase=WBGene00000535\|UniProtKB=G5EDZ9
					family	PTHR46186
				NCBI	gene	177372
				RefSeq	protein	NM_068514.6
				SwissProt	UniProtAcc	G5EDZ9
				UniProt_GCRP	UniProtAcc	G5EDZ9
				OMIM	gene	601891
						604312
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:21	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	04 Jan 2006 11:25:27	WBPerson2970	Name_change	CGC_name	cpi-1
								Other_name	cli-2
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	cpi
		Allele (20)
		Strain	WBStrain00031872
			WBStrain00054919
		RNASeq_FPKM (74)
		GO_annotation	00015098
			00015099
			00015100
			00015101
			00015102
			00015103
			00015104
			00015105
			00015106
			00107561
		Ortholog (73)
		Paralog	WBGene00000534	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00016523	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00023486	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	cpi-1 encodes a homolog of cysteine protease inhibitors (cystatins); cpi-1 is at least superficially dispensable for viability and gross morphology.	Paper_evidence	WBPaper00005654
						WBPaper00012890
					Curator_confirmed	WBPerson567
					Date_last_updated	16 Jul 2007 00:00:00
			Automated_description	Enables cysteine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; CST3-related cerebral amyloid angiopathy; artery disease (multiple); and autoimmune disease of the nervous system (multiple). Is an ortholog of human CST1 (cystatin SN); CST3 (cystatin C); and CST4 (cystatin S).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model (17)
	Molecular_info	Corresponding_CDS	K08B4.6
		Corresponding_transcript	K08B4.6.1
		Other_sequence (14)
		Associated_feature	WBsf651835
			WBsf230135
	Experimental_info	RNAi_result	WBRNAi00089361	Inferred_automatically	RNAi_primary
			WBRNAi00034106	Inferred_automatically	RNAi_primary
			WBRNAi00089116	Inferred_automatically	RNAi_primary
			WBRNAi00089348	Inferred_automatically	RNAi_primary
			WBRNAi00050231	Inferred_automatically	RNAi_primary
			WBRNAi00016775	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1027924
			Expr1153925
			Expr2010489
			Expr2028729
		Drives_construct	WBCnstr00037466
		Construct_product	WBCnstr00037466
		Microarray_results (16)
		Expression_cluster	WBPaper00005700:secreted_protein
			WBPaper00025192:hda-1(RNAi)_upregulated
			WBPaper00031040:Cluster_5
			WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00032031:DConiospora_downregulated_cDNA_12h
			WBPaper00032031:DConiospora_downregulated_cDNA_24h
			WBPaper00032528:L3_enriched
			WBPaper00033444:BacteriaDiet_regulated
			WBPaper00035269:cde-1_regulated
			WBPaper00037047:aging_accelerated_insoluble_protein
			WBPaper00037047:insoluble_protein
			WBPaper00037682:sma-2_downregulated
			WBPaper00037682:sma-2_sma-4_downregulated
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:coelomocytes_embryo_enriched
			WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
			WBPaper00037950:coelomocytes_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:dopaminergic-neurons_larva_enriched
			WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:germline-precursors_embryo_enriched
			WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:hypodermis_larva_enriched
			WBPaper00037950:hypodermis_larva_SelectivelyEnriched
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038118:stress_upregulated_N2
			WBPaper00038168:lin-15B(n744)_upregulated
			WBPaper00038213:E.coli(LF82)_24h_upregulated
			WBPaper00038289:oocyte_protein
			WBPaper00038357:atx-3_regulated_heat-shock
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
			WBPaper00040221:DAF-12_target_ALF4
			WBPaper00040412:germline-regulated_daf-16_target
			WBPaper00044260:1-methylnicotinamide_downregulated
			WBPaper00044260:nicotic-acid_downregulated
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044736:rising_dev_expression
			WBPaper00044746:aging_upregulated_Day5
			WBPaper00044746:aging_upregulated_HeatShock
			WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
			WBPaper00045420:fertilization_downregulated_protein
			WBPaper00045521:Spermatogenic
			WBPaper00045571:germline-ablation_upregulated
			WBPaper00045934:wrn-1(gk99)_downregulated
			WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
			WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00048579:aging_upregulated
			WBPaper00048657:plep-1(ttTi53821)_regulated
			WBPaper00048980:aging_upregulated
			WBPaper00048988:daf-2(e1370)_upregulated_neuron
			WBPaper00048988:neuron_expressed
			WBPaper00049177:rpn-10(ok1865)_downregulated
			WBPaper00049217:DAF-16_upregulated
			WBPaper00049325:CB4856_vs_N2_DEG
			WBPaper00049368:daf-2(e1370)_upregulated
			WBPaper00049498:npr-1(ur89)_regulated_6
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
			WBPaper00049905:Age_variant_expression
			WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_downregulated
			WBPaper00049954:BPS_upregulated
			WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
			WBPaper00050332:daf-16(RNAi)_downregulated
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
			WBPaper00050801:DAF-12_dauer_regulome
			WBPaper00050801:DAF-16_dauer_regulome
			WBPaper00050801:DPY-21_dauer_regulome
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
			WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
			WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051257:Levamisole_upregulated
			WBPaper00051265:F4_hrde-1(tm1200)_downregulated
			WBPaper00051265:F4_morc-1(tm6048)_downregulated
			WBPaper00051305:vit-2(ac3)_downregulated
			WBPaper00051404:alg-1(gk214)_downregulated
			WBPaper00051404:alg-2(ok304)_downregulated
			WBPaper00052884:emb-4(hc60)_upregulated
			WBPaper00053023:nlg-1(ok259)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053295:lin-22(ot267)_upregulated
			WBPaper00053295:lin-22(ot269)_upregulated
			WBPaper00053302:alovudine_72h_regulated
			WBPaper00053308:NMD(-)_upregulated_SMD-2_non-binding_ClassIII
			WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
			WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
			WBPaper00053388:dauer_regulated_Cluster4
			WBPaper00053599:female_vs_male_downregulated
			WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
			WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
			WBPaper00053615:SMO-1_target
			WBPaper00053657:JU2519_M.humicola-infection_24hr
			WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
			WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
			WBPaper00053792:Ochrobactrum_upregulated
			WBPaper00053810:daf-2(e1370)_upregulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00053814:25C_upregulated_OP50
			WBPaper00053814:25C_upregulated_PY79
			WBPaper00053814:OP50_vs_PY79_upregulated_PY79
			WBPaper00054191:H3.3(null)_embryo_upregulated
			WBPaper00054191:H3.3(null)_L1_downregulated
			WBPaper00054192:cold-shock_upregulated
			WBPaper00054758:alg-1(gk204)_downregulated
			WBPaper00055049:S.gordonii_upregulated
			WBPaper00055354:Psora-Allantoin_downregulated
			WBPaper00055354:Psora_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Metformin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin_downregulated
			WBPaper00055354:Rapamycin_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rifampicin-Psora_downregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00055482:pmt-2(RNAi)_downregulated
			WBPaper00055626:pry-1(mu38)_downregulated
			WBPaper00055648:vulva-uterus_expressed
			WBPaper00055827:daf-2(e1370)_upregulated
			WBPaper00055971:nhl-2(ok818)_20C_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00055981:fog-2(q71)_upregulated
			WBPaper00056039:efa-6(tm3124)_downregulated
			WBPaper00056090:E.faecalis_downregulated_N2
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056090:hpx-2(dg047)_upregulated_E.faecalis
			WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
			WBPaper00056218:daf-16(mu86)_upregulated_Day5
			WBPaper00056218:daf-16(mu86)_upregulated_Day7
			WBPaper00056443:sek-1(km4)_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00057006:DietaryRestriction_downregulated
			WBPaper00057068:ints-4(RNAi)_upregulated
			WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
			WBPaper00057143:ztf-11(RNAi)_upregulated
			WBPaper00057154:HeatShock_upregulated_mRNA
			WBPaper00057162:meg-3_meg-4_upregulated_sRNA
			WBPaper00058598:mex-1(or286)_upregulated
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058598:spn-4(tm291)_upregulated
			WBPaper00058691:cfp-1(tm6369)_upregulated
			WBPaper00058711:skn-1(lax188)_downregulated
			WBPaper00059117:B.subtilis_downregulated
			WBPaper00059224:tph-1(mg280)_upregulated
			WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
			WBPaper00059529:skih-2(cc2854)_upregulated
			WBPaper00059537:ngn-1(ok2200)_upregulated
			WBPaper00059566:wdr-23(mac32)_upregulated
			WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059763:neuron_acr-2(n2420gf)_regulated
			WBPaper00059816:crh-1(n3315)_downrgulated
			WBPaper00059824:rnp-6(dh1127)_regulated_OP50
			WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
			WBPaper00059895:wounding_upregulated
			WBPaper00059987:Wounding_upregulated
			WBPaper00060014:set-2(zr2012)_upregulated
			WBPaper00060100:SiNP_downregulated_mRNA
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060459:bcat-1(RNAi)_downregulated
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060703:nas-38(ok3407)_upregulated
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060871:M.humicola-extract_4h_regulated
			WBPaper00060871:M.humicola-infection_12h_regulated
			WBPaper00061045:Y56A3A.22(cck200)_upregulated
			WBPaper00061274:hypergravity_15xg_upregulated
			WBPaper00061340:Rectal_gland
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061527:W01F3.2_1554-Y106G6D.8
			WBPaper00061651:Coelomocyte_enriched
			WBPaper00061651:Rectal_gland_enriched
			WBPaper00061699:daf-18(ok480)_downregulated
			WBPaper00061823:mex-3(spr9)_downregulated
			WBPaper00061902:camt-1(ok515)_regulated_RMG
			WBPaper00062002:Day4-adult_secretome
			WBPaper00062078:NMR-HspB1_regulated
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062347:blmp-1(tm548)_upregulated
			WBPaper00062354:H.zoospora_6h_regulated
			WBPaper00062440:crh-1(n3315)_downregulated
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064005:starvation_downregulated_N2_mRNA
			WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
			WBPaper00064055:trl-1(cas1077)_downregulated_starved
			WBPaper00064055:trl-1(cas1078)_downregulated_non-starved
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064156:lbp-3(overexpress)_downregulated
			WBPaper00064156:lipl-4(overexpress)_downregulated
			WBPaper00064306:Agaro-oligosaccharides_upregulated
			WBPaper00064315:mes-3(bn199)_upregulated_EGCs
			WBPaper00064315:mes-4(bn73)_upregulated_EGCs
			WBPaper00064632:daf-2(e1370)_upregulated_intestine
			WBPaper00064716:paraquat_downregulated
			WBPaper00064727:daf-2(e1370)_upregulated
			WBPaper00064728:cpl-1(W32AY35A)_upregulated
			WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
			WBPaper00064769:him-17(me24)_upregulated
			WBPaper00064850:glh-1(sam65)_upregulated
			WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
			WBPaper00064952:Day10_vs_Day1_upregulated_25C
			WBPaper00064952:Day10_vs_L4_upregulated_25C
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065158:25C_vs_15C_upregulated_AFD
			WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
			WBPaper00065373:Cisplatin_upregulated_WT
			WBPaper00065373:sek-1(km4)_downregulated_cisplatin
			WBPaper00065373:sek-1(km4)_downregulated_Ref
			WBPaper00065581:hpk-1(pk1393)_downregulated
			WBPaper00065623:60
			WBPaper00065734:unc-25(e156)_downregulated
			WBPaper00065835:Day5_vs_Day1_upregulated
			WBPaper00065835:Day11_vs_Day1_upregulated
			WBPaper00065841:11_1
			WBPaper00065841:11_2
			WBPaper00065841:11_3
			WBPaper00065841:18_0
			WBPaper00065841:26_2
			WBPaper00065841:30_3
			WBPaper00065841:146_0
			WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
			WBPaper00065975:P-body_vs_oocyte_depleted
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066085:sin-3(syb2172)_upregulated
			WBPaper00066085:sin-3(tm1276)_upregulated
			WBPaper00066118:cyclobutrifluram_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
			cgc4386_cluster_3_1
			cgc4489_group_12
			WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00028474:dys-1_downregulated
			WBPaper00029437:dcr-1_upregulated
			WBPaper00030985:Erwinia_carotovora_upregulated
			WBPaper00031003:24hr_muscle_depleted
			WBPaper00031003:hlh_1_enriched
			WBPaper00031003:total_muscle_depleted
			WBPaper00031060:2-deoxy-D-glucose_upregulated
			WBPaper00033101:spr-5_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00035873:osm-11_regulated
			WBPaper00035905:FBF-1_Associated
			WBPaper00036286:Pattern_F
			WBPaper00038231:Cry5B_1.5-fold_upregulated
			WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
			WBPaper00040823:alg-1(gk214)_upregulated
			WBPaper00040858:eQTL_age_regulated_aging
			WBPaper00040858:eQTL_regulated_old
			WBPaper00040876:mir-35_upregulated
			WBPaper00041606:CE_B.thuringiensis-DB27_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00042258:DA1877_upregulated_YoungAdult
			WBPaper00042274:tbx-2(bx59)_upregulated
			WBPaper00045263:nuo-6(qm200)_upregulated
			WBPaper00046548:dafachronic-acid_downregulated
			WBPaper00047070:xpa-1_UV_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
			WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
			WBPaper00048989:N2_rapamycin_downregulated
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_SM
			[cgc5976]:class_1
			[cgc6390]:Cluster_A
		Interaction (190)
	Map_info	Map	IV	Position	2.96435	Error	0.003526
		Positive	Positive_clone	K08B4	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4900
		Pseudo_map_position
	Reference (13)
	Remark	Sequence connection from [Hashmi S, Lustigan S], [krb 020711]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
		cpi-1 is also an other_name of cpin-1 (WBGene000000775)	Person_evidence	WBPerson531
	Method	Gene