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WormBase Tree Display for Gene: WBGene00000534

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Name Class

WBGene00000534SMapS_parentSequenceR01B10
IdentityVersion2
NameCGC_namecpi-2Paper_evidenceWBPaper00026724
WBPaper00005846
WBPaper00024997
Person_evidenceWBPerson4368
WBPerson390
Sequence_nameR01B10.1
Molecular_nameR01B10.1a
R01B10.1a.1
CE25962
R01B10.1b
Other_namecli-1
CELE_R01B10.1Accession_evidenceNDBBX284605
Public_namecpi-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
204 Jan 2006 11:04:12WBPerson2970Name_changeCGC_namecpi-2
Other_namecli-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcpi
Allele (30)
StrainWBStrain00031908
WBStrain00054915
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (48)
ParalogWBGene00000535Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00016523Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00023486Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionAutomated_descriptionEnables cysteine-type endopeptidase inhibitor activity. Involved in positive regulation of vitellogenesis; regulation of oocyte development; and regulation of protein processing. Located in extracellular space and yolk granule. Expressed in hypodermis; pharyngeal gland cell; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; CST3-related cerebral amyloid angiopathy; artery disease (multiple); and autoimmune disease of the nervous system (multiple). Is an ortholog of several human genes including CST1 (cystatin SN); CST2 (cystatin SA); and CST3 (cystatin C).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (17)
Molecular_infoCorresponding_CDSR01B10.1a
Corresponding_transcriptR01B10.1b
R01B10.1a.1
Other_sequence (85)
Associated_featureWBsf028073
WBsf646851
WBsf655095
WBsf661303
WBsf661304
WBsf661305
WBsf1000163
WBsf231832
Experimental_infoRNAi_result (11)
Expr_patternExpr3711
Expr7868
Expr7869
Expr1020802
Expr1030320
Expr1154795
Expr2010490
Expr2028730
Drives_constructWBCnstr00012962
Construct_productWBCnstr00012962
AntibodyWBAntibody00001122
Microarray_results (31)
Expression_clusterWBPaper00005700:secreted_protein
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:stress_upregulated_N2
WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_upregulated_Day5
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00045420:fertilization_downregulated_protein
WBPaper00045521:Gender_Neutral
WBPaper00045971:tunicamycin_upregulated_RtcB(null)
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_downregulated
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053289:DREAM-target
WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061340:Coelomocyte
WBPaper00061340:DD
WBPaper00061340:g1A_g1P
WBPaper00061340:GLR
WBPaper00061340:hmc
WBPaper00061340:hmc_and_homolog
WBPaper00061340:hmc_homolog
WBPaper00061340:Parent_of_PVP_and_rect_V
WBPaper00061340:rect_D
WBPaper00061340:RMED
WBPaper00061340:Z1_Z4
WBPaper00061527:172183_at-176110_at
WBPaper00061527:fbxc-28-sdz-28
WBPaper00061651:CAN_enriched
WBPaper00061651:Coelomocyte_enriched
WBPaper00061651:DVB_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064716:paraquat_downregulated
WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
WBPaper00064952:Day5_vs_L4_upregulated_25C
WBPaper00064952:Day10_vs_L4_upregulated_25C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4489_group_21
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026980:intestine_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034757:up_by_oxidative_stress
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036286:Pattern_F
WBPaper00037113:CPF_16C_down-regulated
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
InteractionWBInteraction000143932
WBInteraction000306622
WBInteraction000552020
WBInteraction000577508
Map_infoMapVPosition-0.400385Error0.008156
PositivePositive_cloneR01B10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4964
4240
Pseudo_map_position
Reference (12)
RemarkSequence connection from [Hashmi S, Lustigan S], [krb 020711]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene