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WormBase Tree Display for Gene: WBGene00000497

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Name Class

WBGene00000497SMapS_parentSequenceF48A11
IdentityVersion3
NameCGC_namechs-2Person_evidenceWBPerson50
Sequence_nameF48A11.1
Molecular_nameF48A11.1a
F48A11.1a.1
CE39155
F48A11.1b
CE50690
F48A11.1c
CE50769
F48A11.1b.1
F48A11.1c.1
Other_namechs-1
chi-2CGC_data_submission
CELE_F48A11.1Accession_evidenceNDBBX284602
Public_namechs-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
205 Jul 2004 10:24:20WBPerson1971Name_changeCGC_namechs-2
330 Apr 2015 13:34:49WBPerson1983EventAcquires_mergeWBGene00018583
Acquires_mergeWBGene00018583
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classchs
Allele (220)
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (47)
ParalogWBGene00000496Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionchs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 isrequired for synthesis of chitin lining the inner pharyngeal surface(primarily in the buccal cavity and grinder), while CHS-1 is dispensablefor pharyngeal chitin; CHS-2 is also required for normal pharyngealshape and function, and for larval viability; chs-2(RNAi) animals haveabnormally large, misshapen grinders, and arrest as early larvae; chs-2is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 andm4 myoepithelial cells; chs-2 is transcribed in short periods beforeeach larval molt; the pharyngeal expression of chs-2 parallels gna-1;CHS-2 is predicted to be in the plasma membrane rather than the Golgiapparatus.Paper_evidenceWBPaper00004881
WBPaper00006390
WBPaper00012846
WBPaper00026721
WBPaper00028588
WBPaper00029233
Curator_confirmedWBPerson567
Date_last_updated07 Apr 2007 00:00:00
Automated_descriptionPredicted to enable chitin synthase activity. Involved in chitin biosynthetic process and positive regulation of nematode larval development. Predicted to be located in cell periphery and cell septum. Expressed in pharynx.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF48A11.1a
F48A11.1b
F48A11.1c
Corresponding_CDS_historyF48A11.1:wp149
Corresponding_transcriptF48A11.1a.1
F48A11.1b.1
F48A11.1c.1
Other_sequence (17)
Associated_feature (17)
Experimental_infoRNAi_result (14)
Expr_patternExpr3654
Expr11043
Expr1021151
Expr1024170
Expr1030293
Expr1151543
Expr1151544
Expr2010000
Expr2028241
Drives_constructWBCnstr00009128
WBCnstr00011575
WBCnstr00017872
WBCnstr00023060
Microarray_results (48)
Expression_clusterWBPaper00032528:L3_depleted
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00040221:DAF-12_target_ALF9
WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044760:somatic_specific
WBPaper00044786:emr-1(gk119)_upregulated
WBPaper00045316:prg-1_downregulated_L1
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045521:Spermatogenic
WBPaper00045774:clk-1_downregulated
WBPaper00046805:P-granule-RNAi_downregulated_Set1
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_4
WBPaper00049498:npr-1(ur89)_regulated_7
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050182:lmn-1(L535P)_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050843:sesamin_downregulated
WBPaper00050990:pharynx_enriched
WBPaper00050990:pharynx_expressed
WBPaper00051305:vit-2(ac3)_upregulated
WBPaper00053020:OrsayVirus-infection_downregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053599:female_vs_male_downregulated
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_PY79
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:hmg-4(RNAi)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:sperm_expressed
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056169:rrf-3(pk1426)_downregulated_L3
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056169:rrf-3(pk1426)_upregulated_L2
WBPaper00056330:glycine_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057068:ints-4(RNAi)_downregulated
WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
WBPaper00057162:meg-3_meg-4_downregulated_sRNA
WBPaper00057288:Cold_upregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058942:henn-1(pk2295)_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059117:B.subtilis_upregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059605:mut-16(pk710)_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(et18)_downregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AIA
WBPaper00061340:Anterior_arcade_cell
WBPaper00061340:ant_arc_V
WBPaper00061340:Arcade_cell_anterior_and_posterior
WBPaper00061340:pm1_pm2
WBPaper00061340:pm3_pm4_pm5
WBPaper00061340:Posterior_arcade_cell
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061527:176662_at-Y53F4B.16
WBPaper00061527:R12A1.3-M195.2
WBPaper00061527:srj-21-srh-32
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00061952:daf-18(nr2037)_upregulated
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065258:anchor-cell_depleted
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065841:4_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066038:mip-1(how5)_upregulated
WBPaper00066085:sin-3(tm1276)_downregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_20
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027111:rrf-2(ok210)_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00036123:Atrazine_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_E
WBPaper00037147:heatshock_upregulated
WBPaper00038172:crh-1null_down_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040876:mir-35_downregulated
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045294:50uM_DBAA_downregulated
WBPaper00045294:50uM_TBBP_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:Cluster_C
InteractionWBInteraction000241924
WBInteraction000463268
Map_infoMapIIPosition-15.8229Error0.018071
PositivePositive_cloneF48A11Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (12)
RemarkGene was renamed from chi-2 to chs-2 at request of CGC, note that the other name 'chs-1' is from the Brugia malayi ortholog...this ortholog may be renamed in the future to clarify the situation.CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene