chs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 isrequired for synthesis of chitin lining the inner pharyngeal surface(primarily in the buccal cavity and grinder), while CHS-1 is dispensablefor pharyngeal chitin; CHS-2 is also required for normal pharyngealshape and function, and for larval viability; chs-2(RNAi) animals haveabnormally large, misshapen grinders, and arrest as early larvae; chs-2is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 andm4 myoepithelial cells; chs-2 is transcribed in short periods beforeeach larval molt; the pharyngeal expression of chs-2 parallels gna-1;CHS-2 is predicted to be in the plasma membrane rather than the Golgiapparatus.
Predicted to enable chitin synthase activity. Involved in chitin biosynthetic process and positive regulation of nematode larval development. Predicted to be located in cell periphery and cell septum. Expressed in pharynx.
Gene was renamed from chi-2 to chs-2 at request of CGC, note that the other name 'chs-1' is from the Brugia malayi ortholog...this ortholog may be renamed in the future to clarify the situation.
CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.