WormBase Tree Display for Gene: WBGene00000445
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| WBGene00000445 | SMap | S_parent | Sequence | F29F11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ceh-22 | Person_evidence | WBPerson83 | |||||
| Sequence_name | F29F11.5 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | sys-3 | Paper_evidence | WBPaper00027082 | ||||||
| Person_evidence | WBPerson320 | ||||||||
| CELE_F29F11.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ceh-22 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00000445 | |||||
| SignaLink | protein | WBGene00000445 | |||||||
| WormFlux | gene | WBGene00000445 | |||||||
| NDB | locus_tag | CELE_F29F11.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000445|UniProtKB=P41936 | |||||||
| family | PTHR24340 | ||||||||
| NCBI | gene | 179485 | |||||||
| RefSeq | protein | NM_001083274.3 | |||||||
| NM_001356739.4 | |||||||||
| NM_001083275.4 | |||||||||
| NM_001083273.4 | |||||||||
| NM_001356738.3 | |||||||||
| SwissProt | UniProtAcc | P41936 | |||||||
| TrEMBL | UniProtAcc | A0A2C9C3N2 | |||||||
| A0A2C9C312 | |||||||||
| UniProt_GCRP | UniProtAcc | P41936 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Dec 2006 14:52:18 | WBPerson1847 | Event | Acquires_merge | WBGene00007040 | ||||
| Name_change | Other_name | sys-3 | |||||||
| Acquires_merge | WBGene00007040 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Reference_allele | WBVar00239183 | ||||||||
| Allele (54) | |||||||||
| Legacy_information | cc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila. Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994] | ||||||||
| [C.elegansII] cc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila.Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994] | |||||||||
| Strain | WBStrain00029938 | ||||||||
| WBStrain00029950 | |||||||||
| WBStrain00030611 | |||||||||
| WBStrain00002782 | |||||||||
| WBStrain00022585 | |||||||||
| WBStrain00022629 | |||||||||
| WBStrain00030612 | |||||||||
| WBStrain00029939 | |||||||||
| WBStrain00049270 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00000428 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000434 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000447 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000584 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000449 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000450 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ceh-22 encodes an NK-2 family homeodomain factor homologous to Drosophila TINMAN and vertebrate Nkx2-5 proteins; CEH-22 activates pharyngeal muscle gene expression in combination with PHA-1 and is required for normal pharyngeal development; ceh-22 is the first gene known to be expressed in pharyngeal muscles, being exclusively active in that tissue. | Paper_evidence | WBPaper00005167 | |||||
| WBPaper00002925 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Feb 2014 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00060633 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jun 2021 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000949 | ||||||||
| WBDOannot00000954 | |||||||||
| WBDOannot00000961 | |||||||||
| WBDOannot00000962 | |||||||||
| Molecular_info | Corresponding_CDS | F29F11.5a | |||||||
| F29F11.5b | |||||||||
| F29F11.5c | |||||||||
| F29F11.5d | |||||||||
| F29F11.5e | |||||||||
| Corresponding_transcript | F29F11.5a.1 | ||||||||
| F29F11.5b.1 | |||||||||
| F29F11.5c.1 | |||||||||
| F29F11.5d.1 | |||||||||
| F29F11.5e.1 | |||||||||
| Other_sequence | Acan_isotig04736 | ||||||||
| Oden_isotig21208 | |||||||||
| CBC02288_1 | |||||||||
| MI05158 | |||||||||
| MIC04433_1 | |||||||||
| JI177847.1 | |||||||||
| Associated_feature (24) | |||||||||
| Gene_product_binds (135) | |||||||||
| Transcription_factor | WBTranscriptionFactor000061 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00071562 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00014111 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031582 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115657 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027310 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069884 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025316 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045934 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (23) | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000082 | ||||||||
| WBAntibody00000083 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (111) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| WBbiopr:00000114 | |||||||||
| Map_info | Map | V | Position | 2.70908 | Error | 0.00321 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F29F11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y24E3 | |||||||||
| Y33F10 | |||||||||
| Y59H10 | |||||||||
| Y61D5 | |||||||||
| Mapping_data | Multi_point | 3789 | |||||||
| Pos_neg_data | 8351 | ||||||||
| 8352 | |||||||||
| 8353 | |||||||||
| 8354 | |||||||||
| 8355 | |||||||||
| Reference (88) | |||||||||
| Method | Gene |
