WormBase Tree Display for Gene: WBGene00000438
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| WBGene00000438 | SMap | S_parent | Sequence | F46C8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-14 | Person_evidence | WBPerson83 | |||||
| Sequence_name | F46C8.5 | ||||||||
| Molecular_name | F46C8.5 | ||||||||
| F46C8.5.1 | |||||||||
| CE28335 | |||||||||
| Other_name | CELE_F46C8.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | ceh-14 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (96) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes LIM class homeoprotein.[Burglin et al. 1989] | ||||||||
| [C.elegansII] NMK. Encodes LIM class homeoprotein. [Burglin et al. 1989] | |||||||||
| Strain | WBStrain00035292 | ||||||||
| WBStrain00035293 | |||||||||
| WBStrain00003289 | |||||||||
| WBStrain00034656 | |||||||||
| WBStrain00034657 | |||||||||
| WBStrain00029930 | |||||||||
| WBStrain00045543 | |||||||||
| WBStrain00051843 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00003167 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006654 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003000 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00002989 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WBGene00002987 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00002988 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006824 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015216 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017644 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022518 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ceh-14 encodes a LIM homeodomain protein orthologous to Drosophila Lim3 and the vertebrate Lhx3 and Lhx4 proteins; ceh-14 is required for specification of the AFD thermosensory neurons and for normal thermotactic behavior; a ceh-14::GFP reporter fusion is expressed in head and tail neurons, including the AFD thermosensory neurons, during late embryonic, larval, and adult stages. Animals triply mutant for the LIM homeobox genes ceh-14, lin-11, and ttx-3 which are required for function of the AFD, AIZ, and AIY neurons, respectively, exhibit a basic cryophilic thermotaxis response suggesting that, in C. elegans, there is more than one pathway for integration of thermosensory input. | Paper_evidence | WBPaper00003981 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Jun 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in nucleus. Expressed in several structures, including hypodermal cell; neurons; somatic nervous system; spermatheca; and tail. Human ortholog(s) of this gene implicated in panhypopituitarism. Is an ortholog of human LHX3 (LIM homeobox 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9410 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21734,HGNC:6595) | ||||
| Molecular_info | Corresponding_CDS | F46C8.5 | |||||||
| Corresponding_transcript | F46C8.5.1 | ||||||||
| Other_sequence | Tcir_isotig08755 | ||||||||
| Dviv_isotig17431 | |||||||||
| WBC01851_1 | |||||||||
| CK850438.1 | |||||||||
| CRC10702_1 | |||||||||
| AS02023 | |||||||||
| JI173895.1 | |||||||||
| FG582906.1 | |||||||||
| CR04794 | |||||||||
| Dviv_isotig17430 | |||||||||
| Associated_feature (19) | |||||||||
| Gene_product_binds (1357) | |||||||||
| Transcription_factor | WBTranscriptionFactor000017 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00063283 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00032362 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084773 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063287 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000726 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047517 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063286 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063284 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00007779 | ||||||||
| WBCnstr00015368 | |||||||||
| WBCnstr00018906 | |||||||||
| WBCnstr00020156 | |||||||||
| WBCnstr00037539 | |||||||||
| Regulate_expr_cluster | WBPaper00066004:ceh-14(ch3)_downregulated | ||||||||
| WBPaper00066004:ceh-14(ch3)_upregulated | |||||||||
| Antibody | WBAntibody00000273 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (176) | |||||||||
| Map_info | Map | X | Position | -1.63056 | Error | 0.011991 | |||
| Positive | Positive_clone | F46C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| XXF5 | |||||||||
| Mapping_data | Multi_point | 4203 | |||||||
| Pseudo_map_position | |||||||||
| Reference (81) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
