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WormBase Tree Display for Gene: WBGene00006824

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Name Class

WBGene00006824EvidencePaper_evidenceWBPaper00019431
SMapS_parentSequenceY105E8A
IdentityVersion1
NameCGC_nameunc-95Person_evidenceWBPerson261
Sequence_nameY105E8A.6
Molecular_nameY105E8A.6
Y105E8A.6.1
CE31857
Other_nameY105E8E.eCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y105E8A.6Accession_evidenceNDBBX284601
Public_nameunc-95
DB_infoDatabaseAceViewgene1O974
WormQTLgeneWBGene00006824
WormFluxgeneWBGene00006824
NDBlocus_tagCELE_Y105E8A.6
NCBIgene173301
RefSeqproteinNM_170938.7
SwissProtUniProtAccQ9NEZ5
UniProt_GCRPUniProtAccQ9NEZ5
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (65)
Legacy_informationsu106sd : very slow or paralysed Egl; abnormal variable muscle birefringence disorganized sarcomeres with collections of thin filaments. ES3. NA4 (su33amber (simialr phenotypes ME0) etc.).
[C.elegansII] su106sd : very slow or paralysed, Egl; abnormal variable muscle birefringence, disorganized sarcomeres with collections of thin filaments. ES3. OA3: su33amb (similar phenotypes, ME0), etc. [Zengel and Epstein 1980; HE]
StrainWBStrain00035931
WBStrain00008387
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (29)
ParalogWBGene00000438Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002987Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002988Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003000Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003167Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006654Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015216Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00017644Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00022518Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-95 encodes a LIM domain-containing protein related to Drosophila and vertebrate paxillins; UNC-95 is required for locomotion and organization of thick and thin filaments in body wall muscle; by homology, UNC-95 may function as an anchor protein that links signaling and cytoskeletal proteins at focal adhesions; in vitro, UNC-95 interacts with RNF-5, a RING finger protein that may function as an E3 ligase to regulate UNC-95 levels via ubiquitin-mediated degradation; UNC-95 is expressed in body-wall and vulval muscles, and co-localizes with RNF-5 to muscle dense bodies (focal adhesion-like attachment sites).Paper_evidenceWBPaper00000488
WBPaper00013295
WBPaper00019431
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables protein domain specific binding activity. Located in M band; nucleus; and striated muscle dense body.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY105E8A.6
Corresponding_CDS_historyY105E8A.6:wp86
Corresponding_transcriptY105E8A.6.1
Other_sequence (34)
Associated_featureWBsf649756
WBsf665123
WBsf979068
WBsf986146
WBsf986147
WBsf1011238
WBsf220605
WBsf220606
WBsf220607
WBsf220608
Transcription_factorWBTranscriptionFactor000438
Experimental_infoRNAi_result (13)
Expr_patternExpr2991
Expr2992
Expr8314
Expr8542
Expr1012404
Expr1032888
Expr1158771
Expr2017921
Expr2036057
Drives_constructWBCnstr00006034
WBCnstr00011070
WBCnstr00011071
WBCnstr00013356
WBCnstr00034135
Construct_productWBCnstr00006034
WBCnstr00013356
WBCnstr00034135
Regulate_expr_clusterWBPaper00031097:unc-95(su33)_upregulated
AntibodyWBAntibody00001286
Microarray_results (18)
Expression_cluster (157)
Interaction (56)
WBProcessWBbiopr:00000006
Map_infoMapIPosition24.674Error0.00615
Well_ordered
PositivePositive_cloneY105E8AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point392
393
394
3684
3685
7080
Multi_point2332
4894
Pos_neg_data5109
5110
5111
5112
5113
5114
5115
Reference (31)
MethodGene