WormBase Tree Display for Gene: WBGene00000406
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WBGene00000406 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | cdk-4 | Person_evidence | WBPerson346 | |||||
Sequence_name | F18H3.5 | ||||||||
Molecular_name | F18H3.5 | ||||||||
F18H3.5.1 | |||||||||
CE18608 | |||||||||
Other_name | CELE_F18H3.5 | Accession_evidence | NDB | BX284606 | |||||
Public_name | cdk-4 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cdk | ||||||||
Allele (67) | |||||||||
Legacy_information | [Krause MW] cdk-4 is a cyclin dependent kinase related to cdk-4 and cdk-6 from other organims. Homozygous cdk-4(gv3) animals usually arrest in L2 due to no, or limited, proliferation of the post-embryonic blast cells. About 3% of animals make it to a late stage of development. | ||||||||
Strain | WBStrain00023588 | ||||||||
WBStrain00034600 | |||||||||
WBStrain00034601 | |||||||||
WBStrain00003937 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (36) | |||||||||
Ortholog (43) | |||||||||
Paralog | WBGene00000405 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00019362 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00012779 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00013917 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00015203 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00000410 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00007135 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00010349 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00000409 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00000408 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00022519 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00003961 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00000407 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004186 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00008095 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00016464 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00016465 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. | Paper_evidence | WBPaper00003752 | |||||
WBPaper00004192 | |||||||||
WBPaper00005298 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables protein serine/threonine kinase activity. Involved in nematode larval development; positive regulation of cell cycle process; and reproductive process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00046296 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 04 Feb 2015 00:00:00 | ||||||||
Potential_model (24) | |||||||||
Models_disease_in_annotation | WBDOannot00000346 | ||||||||
Molecular_info | Corresponding_CDS | F18H3.5 | |||||||
Corresponding_CDS_history | F18H3.5b:wp61 | ||||||||
F18H3.5b:wp271 | |||||||||
Corresponding_transcript | F18H3.5.1 | ||||||||
Other_sequence (22) | |||||||||
Associated_feature | WBsf654531 | ||||||||
WBsf671198 | |||||||||
WBsf1007631 | |||||||||
WBsf1024243 | |||||||||
WBsf238141 | |||||||||
Experimental_info | RNAi_result (13) | ||||||||
Expr_pattern | Expr1156 | ||||||||
Expr1017984 | |||||||||
Expr1030223 | |||||||||
Expr1148945 | |||||||||
Expr2009811 | |||||||||
Expr2028052 | |||||||||
Drives_construct | WBCnstr00010112 | ||||||||
WBCnstr00016185 | |||||||||
WBCnstr00020118 | |||||||||
WBCnstr00020130 | |||||||||
WBCnstr00021180 | |||||||||
WBCnstr00037565 | |||||||||
Construct_product | WBCnstr00010112 | ||||||||
WBCnstr00016185 | |||||||||
WBCnstr00020118 | |||||||||
WBCnstr00020130 | |||||||||
WBCnstr00037565 | |||||||||
Regulate_expr_cluster | WBPaper00040426:CYD-1_CDK-4_downregulated | ||||||||
WBPaper00040426:CYD-1_CDK-4_upregulated | |||||||||
Microarray_results (24) | |||||||||
Expression_cluster (137) | |||||||||
Interaction (61) | |||||||||
Map_info | Map | X | Position | 12.6771 | Error | 0.006799 | |||
Positive | Positive_clone | F18H3 | Person_evidence | WBPerson346 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
H06A10 | Person_evidence | WBPerson346 | |||||||
Mapping_data | Multi_point | 4138 | |||||||
4196 | |||||||||
Pseudo_map_position | |||||||||
Reference (36) | |||||||||
Remark | The deletion allele was isolated in a PCR-based screen following the method of Barstead and Moulder. The deletion break points have been identified by sequence. We have rescued the cdk-4(gv3) mutant using a wild type copy of the cdk-4 cDNA expressed under the control of cdk-4 ~3 kb of 5' flanking sequences. | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |