WormBase Tree Display for Gene: WBGene00000409
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| WBGene00000409 | Evidence | Paper_evidence | WBPaper00004192 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F39H11 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdk-8 | Person_evidence | WBPerson346 | |||||
| Sequence_name | F39H11.3 | ||||||||
| Molecular_name | F39H11.3 | ||||||||
| F39H11.3.1 | |||||||||
| CE32409 | |||||||||
| Other_name | CELE_F39H11.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | cdk-8 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdk | ||||||||
| Allele (46) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (41) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Expressed in anchor cell and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87 and dilated cardiomyopathy. Is an ortholog of human CDK19 (cyclin dependent kinase 19) and CDK8 (cyclin dependent kinase 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112221 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19338) | ||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1779) | ||||||
| Molecular_info | Corresponding_CDS | F39H11.3 | |||||||
| Corresponding_CDS_history | F39H11.3:wp90 | ||||||||
| Corresponding_transcript | F39H11.3.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf643545 | ||||||||
| WBsf643546 | |||||||||
| WBsf984482 | |||||||||
| WBsf984483 | |||||||||
| WBsf1010264 | |||||||||
| WBsf218195 | |||||||||
| WBsf218196 | |||||||||
| Transcription_factor | WBTranscriptionFactor000505 | ||||||||
| Experimental_info | RNAi_result (45) | ||||||||
| Expr_pattern | Expr10769 | ||||||||
| Expr12673 | |||||||||
| Expr1017434 | |||||||||
| Expr1030226 | |||||||||
| Expr1150671 | |||||||||
| Expr2009814 | |||||||||
| Expr2028055 | |||||||||
| Drives_construct | WBCnstr00017723 | ||||||||
| WBCnstr00022250 | |||||||||
| WBCnstr00037563 | |||||||||
| Construct_product | WBCnstr00022249 | ||||||||
| WBCnstr00022251 | |||||||||
| WBCnstr00022252 | |||||||||
| WBCnstr00037563 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (99) | |||||||||
| Map_info | Map | I | Position | 3.02024 | Error | 0.003576 | |||
| Positive | Positive_clone | F39H11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4223 | |||||||
| 4728 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
