WormBase Tree Display for Gene: WBGene00000409

WBGene00000409 Evidence: Paper_evidence: WBPaper00004192
  SMap: S_parent: Sequence: F39H11
  Identity: Version: 1
    Name: CGC_name: cdk-8 Person_evidence: WBPerson346
      Sequence_name: F39H11.3
      Molecular_name: F39H11.3
        F39H11.3.1
        CE32409
      Other_name: CELE_F39H11.3 Accession_evidence: NDB BX284601
      Public_name: cdk-8
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdk
    Allele (46)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (41)
    Paralog (17)
    Structured_description: Concise_description: cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. Paper_evidence (11)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Expressed in anchor cell and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87 and dilated cardiomyopathy. Is an ortholog of human CDK19 (cyclin dependent kinase 19) and CDK8 (cyclin dependent kinase 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112221 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19338)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1779)
  Molecular_info: Corresponding_CDS: F39H11.3
    Corresponding_CDS_history: F39H11.3:wp90
    Corresponding_transcript: F39H11.3.1
    Other_sequence (22)
    Associated_feature: WBsf643545
      WBsf643546
      WBsf984482
      WBsf984483
      WBsf1010264
      WBsf218195
      WBsf218196
    Transcription_factor: WBTranscriptionFactor000505
  Experimental_info: RNAi_result (45)
    Expr_pattern: Expr10769
      Expr12673
      Expr1017434
      Expr1030226
      Expr1150671
      Expr2009814
      Expr2028055
    Drives_construct: WBCnstr00017723
      WBCnstr00022250
      WBCnstr00037563
    Construct_product: WBCnstr00022249
      WBCnstr00022251
      WBCnstr00022252
      WBCnstr00037563
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00040209:B.thuringiensis_upregulated_MY18
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049018:SWSN-2.2_interacting
      WBPaper00049626:UNC-75_target
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:URA_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:pch-2-B0393.3
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_193
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037611:RNP-8-associated
      WBPaper00037695:LD_DD_6-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00045263:0.1mM-paraquat_upregulated
      [cgc5767]:cluster_13
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (99)
  Map_info: Map: I Position: 3.02024 Error: 0.003576
    Positive: Positive_clone: F39H11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4223
        4728
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene