WormBase Tree Display for Gene: WBGene00000405
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| WBGene00000405 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T05G5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdk-1 | Person_evidence | WBPerson346 | |||||
| Sequence_name | T05G5.3 | ||||||||
| Molecular_name | T05G5.3 | ||||||||
| T05G5.3.1 | |||||||||
| CE00315 | |||||||||
| Other_name | ncc-1 | ||||||||
| CELE_T05G5.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | cdk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdk | ||||||||
| Allele (23) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes 38 kD protein, homolog of fission yeast p34 cdc2 kinase, 65% identity to human cdc2 but has sequence PSTAVR rather than PSTAIR; can complement some alleles of budding yeast CDC28. [Mori et al. 1994; PS] | ||||||||
| Strain | WBStrain00034591 | ||||||||
| WBStrain00034593 | |||||||||
| WBStrain00034594 | |||||||||
| WBStrain00034595 | |||||||||
| WBStrain00034596 | |||||||||
| WBStrain00036569 | |||||||||
| WBStrain00037334 | |||||||||
| WBStrain00040430 | |||||||||
| WBStrain00040431 | |||||||||
| WBStrain00054806 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (46) | |||||||||
| Ortholog (54) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis; in regulating progression through meiosis and the oocyte-to-egg transition, CDK-1 functions to regulate the activity of the MBK-2 DYRK2 family kinase that phosphorylates a number of substrates to promote the oocyte-to-egg transition; CDK-1 physically interacts with CYB-1 and CYB-3 and demonstrates cyclin-dependent kinase activity in vitro; CDK-1 expression is detected at high levels in embryos, but is also seen in larvae and adults; CDK-1 localizes to nuclei and to the cytoplasm. | Paper_evidence | WBPaper00002097 | |||||
| WBPaper00003554 | |||||||||
| WBPaper00004192 | |||||||||
| WBPaper00035305 | |||||||||
| WBPaper00035427 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 02 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables cyclin-dependent protein serine/threonine kinase activity and protein kinase binding activity. Involved in several processes, including positive regulation of meiotic nuclear division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in embryonic cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including cervical cancer; hepatobiliary system cancer (multiple); and transitional cell carcinoma. Is an ortholog of human CDK1 (cyclin dependent kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||
| DOID:3500 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||||
| DOID:4362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1722) | ||||||
| Molecular_info | Corresponding_CDS | T05G5.3 | |||||||
| Corresponding_transcript | T05G5.3.1 | ||||||||
| Other_sequence (110) | |||||||||
| Associated_feature | WBsf645511 | ||||||||
| WBsf993787 | |||||||||
| WBsf993788 | |||||||||
| WBsf225611 | |||||||||
| Experimental_info | RNAi_result (71) | ||||||||
| Expr_pattern | Expr551 | ||||||||
| Expr1328 | |||||||||
| Expr12835 | |||||||||
| Expr15778 | |||||||||
| Expr15905 | |||||||||
| Expr1010204 | |||||||||
| Expr1030222 | |||||||||
| Expr1156181 | |||||||||
| Expr2009809 | |||||||||
| Expr2028050 | |||||||||
| Drives_construct | WBCnstr00037566 | ||||||||
| Construct_product | WBCnstr00014736 | ||||||||
| WBCnstr00014737 | |||||||||
| WBCnstr00014738 | |||||||||
| WBCnstr00014739 | |||||||||
| WBCnstr00037566 | |||||||||
| Antibody | WBAntibody00000225 | ||||||||
| WBAntibody00001663 | |||||||||
| WBAntibody00002048 | |||||||||
| WBAntibody00002119 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (248) | |||||||||
| Interaction (417) | |||||||||
| WBProcess | WBbiopr:00000068 | ||||||||
| WBbiopr:00000073 | |||||||||
| Map_info | Map | III | Position | 0.96912 | Error | 0.005045 | |||
| Positive | Positive_clone | T05G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4177 | |||||||
| 4195 | |||||||||
| 4435 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (124) | |||||||||
| Remark | Sequence connection from [Golden A] | ||||||||
| old_name ncc-1 becomes new_name cdk-1 from [Golden A]. | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
