WormBase Tree Display for Gene: WBGene00000092

WBGene00000092 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F32A6
  Identity: Version: 1
    Name: CGC_name: ags-3 Person_evidence: WBPerson8
      Sequence_name: F32A6.4
      Molecular_name (22)
      Other_name: ags-3.1
        CELE_F32A6.4 Accession_evidence: NDB BX284606
      Public_name: ags-3
    DB_info: Database: AceView gene XF910
        WormQTL gene WBGene00000092
        WormFlux gene WBGene00000092
        NDB locus_tag CELE_F32A6.4
        Panther gene CAEEL|WormBase=WBGene00000092|UniProtKB=Q19955
          family PTHR45954
        NCBI gene 180801
        RefSeq protein NM_001322619.4
            NR_136376.1
            NM_001322621.4
            NM_171684.6
            NM_001322618.4
            NR_136377.1
            NM_001383577.1
        TrEMBL UniProtAcc A0A131MD77
            A0A131MBA1
            A0A131MBC1
            A0A131MBW5
            Q19955
        UniProt_GCRP UniProtAcc Q19955
        RNAcentral URSid URS00009CD78A
            URS00009E5227
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ags
    Allele (220)
    Strain: WBStrain00001170
      WBStrain00001463
      WBStrain00031847
      WBStrain00036344
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (40)
    Paralog: WBGene00004507 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00021247 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ags-3 encodes a protein containing N-terminal TRP domains and C-terminal GPR domains that is a member of the Activator of G Protein Signaling 3 (AGS3) family of proteins that includes mammalian AGS3 and LPN and Drosophila RAPSYNOID; in C. elegans, AGS-3 is involved in polarity and spindle orientation during early embryogenesis; in addition, AGS-3, along with the RIC-8 guanine nucleotide exchange factor, has been shown to activate GOA-1/Galpha0 in the ASH chemosensory neurons to modulate behavior after food deprivation; full length AGS-3 binds inactive GOA-1 (GOA-1-GDP) in pull down assays, while AGS-3 fragments containing the GPR domains (also known as GoLoco domains) bind activated GOA-1 (GOA-1-GTP) in pull down assays and GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots; in adults, an ags-3 reporter fusion is seen in nearly all neurons, including the ASH chemosensory neurons, and in body wall muscle, egg-laying muscles, and pharyngeal muscles; AGS-3 subcellular localization is regulated by food deprivation: AGS-3 moves from a Triton X-100 insoluble pellet fraction to a Triton X-100 soluble pellet fraction after several hours of food deprivation. Paper_evidence: WBPaper00004782
            WBPaper00005945
            WBPaper00006194
            WBPaper00040078
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 19 Aug 2011 00:00:00
      Automated_description: Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; neurons; and tail. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Is an ortholog of human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10003 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29501)
  Molecular_info: Corresponding_CDS: F32A6.4a
      F32A6.4d
      F32A6.4e
      F32A6.4f
      F32A6.4g
    Corresponding_CDS_history: F32A6.4b:wp252
      F32A6.4c:wp252
    Corresponding_transcript (12)
    Other_sequence (25)
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00046084 Inferred_automatically: RNAi_primary
      WBRNAi00061394 Inferred_automatically: RNAi_primary
      WBRNAi00031648 Inferred_automatically: RNAi_primary
      WBRNAi00063377 Inferred_automatically: RNAi_primary
      WBRNAi00063365 Inferred_automatically: RNAi_primary
      WBRNAi00097948 Inferred_automatically: RNAi_primary
      WBRNAi00088424 Inferred_automatically: RNAi_primary
      WBRNAi00014199 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00002062
      WBCnstr00004206
      WBCnstr00010933
      WBCnstr00013914
    Construct_product: WBCnstr00010933
    Antibody: WBAntibody00002292
    Microarray_results (33)
    Expression_cluster (171)
    Interaction (62)
  Map_info: Map: X Position: -5.74685 Error: 0.011682
    Positive: Positive_clone: F32A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4885
    Pseudo_map_position
  Reference (12)
  Remark: Sequence connection from [Ahringer JA]
    Sequence connection updated by Darin Blasiar, Feb 2002
    Gene renamed from ags-3.1 to ags-3 following advice from [Hodgkin J], [020808 krb]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene