WormBase Tree Display for Gene: WBGene00000092
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| WBGene00000092 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F32A6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ags-3 | Person_evidence | WBPerson8 | |||||
| Sequence_name | F32A6.4 | ||||||||
| Molecular_name (22) | |||||||||
| Other_name | ags-3.1 | ||||||||
| CELE_F32A6.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | ags-3 | ||||||||
| DB_info | Database | AceView | gene | XF910 | |||||
| WormQTL | gene | WBGene00000092 | |||||||
| WormFlux | gene | WBGene00000092 | |||||||
| NDB | locus_tag | CELE_F32A6.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000092|UniProtKB=Q19955 | |||||||
| family | PTHR45954 | ||||||||
| NCBI | gene | 180801 | |||||||
| RefSeq | protein | NM_001322619.4 | |||||||
| NR_136376.1 | |||||||||
| NM_001322621.4 | |||||||||
| NM_171684.6 | |||||||||
| NM_001322618.4 | |||||||||
| NR_136377.1 | |||||||||
| NM_001383577.1 | |||||||||
| TrEMBL | UniProtAcc | A0A131MD77 | |||||||
| A0A131MBA1 | |||||||||
| A0A131MBC1 | |||||||||
| A0A131MBW5 | |||||||||
| Q19955 | |||||||||
| UniProt_GCRP | UniProtAcc | Q19955 | |||||||
| RNAcentral | URSid | URS00009CD78A | |||||||
| URS00009E5227 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ags | ||||||||
| Allele (220) | |||||||||
| Strain | WBStrain00001170 | ||||||||
| WBStrain00001463 | |||||||||
| WBStrain00031847 | |||||||||
| WBStrain00036344 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00004507 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00021247 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ags-3 encodes a protein containing N-terminal TRP domains and C-terminal GPR domains that is a member of the Activator of G Protein Signaling 3 (AGS3) family of proteins that includes mammalian AGS3 and LPN and Drosophila RAPSYNOID; in C. elegans, AGS-3 is involved in polarity and spindle orientation during early embryogenesis; in addition, AGS-3, along with the RIC-8 guanine nucleotide exchange factor, has been shown to activate GOA-1/Galpha0 in the ASH chemosensory neurons to modulate behavior after food deprivation; full length AGS-3 binds inactive GOA-1 (GOA-1-GDP) in pull down assays, while AGS-3 fragments containing the GPR domains (also known as GoLoco domains) bind activated GOA-1 (GOA-1-GTP) in pull down assays and GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots; in adults, an ags-3 reporter fusion is seen in nearly all neurons, including the ASH chemosensory neurons, and in body wall muscle, egg-laying muscles, and pharyngeal muscles; AGS-3 subcellular localization is regulated by food deprivation: AGS-3 moves from a Triton X-100 insoluble pellet fraction to a Triton X-100 soluble pellet fraction after several hours of food deprivation. | Paper_evidence | WBPaper00004782 | |||||
| WBPaper00005945 | |||||||||
| WBPaper00006194 | |||||||||
| WBPaper00040078 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 19 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; neurons; and tail. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Is an ortholog of human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29501) | ||||
| Molecular_info | Corresponding_CDS | F32A6.4a | |||||||
| F32A6.4d | |||||||||
| F32A6.4e | |||||||||
| F32A6.4f | |||||||||
| F32A6.4g | |||||||||
| Corresponding_CDS_history | F32A6.4b:wp252 | ||||||||
| F32A6.4c:wp252 | |||||||||
| Corresponding_transcript (12) | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00046084 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00061394 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031648 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063377 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063365 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097948 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088424 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014199 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002062 | ||||||||
| WBCnstr00004206 | |||||||||
| WBCnstr00010933 | |||||||||
| WBCnstr00013914 | |||||||||
| Construct_product | WBCnstr00010933 | ||||||||
| Antibody | WBAntibody00002292 | ||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction | WBInteraction000029545 | ||||||||
| WBInteraction000166977 | |||||||||
| WBInteraction000167155 | |||||||||
| WBInteraction000184158 | |||||||||
| WBInteraction000188602 | |||||||||
| WBInteraction000192150 | |||||||||
| WBInteraction000193527 | |||||||||
| WBInteraction000202710 | |||||||||
| WBInteraction000205394 | |||||||||
| WBInteraction000206008 | |||||||||
| WBInteraction000206180 | |||||||||
| WBInteraction000208539 | |||||||||
| WBInteraction000211281 | |||||||||
| WBInteraction000211634 | |||||||||
| WBInteraction000216305 | |||||||||
| WBInteraction000216357 | |||||||||
| WBInteraction000232510 | |||||||||
| WBInteraction000239109 | |||||||||
| WBInteraction000240257 | |||||||||
| WBInteraction000242788 | |||||||||
| WBInteraction000255062 | |||||||||
| WBInteraction000255512 | |||||||||
| WBInteraction000260243 | |||||||||
| WBInteraction000265252 | |||||||||
| WBInteraction000267263 | |||||||||
| WBInteraction000271918 | |||||||||
| WBInteraction000283585 | |||||||||
| WBInteraction000301679 | |||||||||
| WBInteraction000313384 | |||||||||
| WBInteraction000319227 | |||||||||
| WBInteraction000327528 | |||||||||
| WBInteraction000366267 | |||||||||
| WBInteraction000382681 | |||||||||
| WBInteraction000386040 | |||||||||
| WBInteraction000388077 | |||||||||
| WBInteraction000397163 | |||||||||
| WBInteraction000411698 | |||||||||
| WBInteraction000449174 | |||||||||
| WBInteraction000511745 | |||||||||
| WBInteraction000511751 | |||||||||
| WBInteraction000511752 | |||||||||
| WBInteraction000511755 | |||||||||
| WBInteraction000511756 | |||||||||
| WBInteraction000511757 | |||||||||
| WBInteraction000511771 | |||||||||
| WBInteraction000522475 | |||||||||
| WBInteraction000524564 | |||||||||
| WBInteraction000542819 | |||||||||
| WBInteraction000542831 | |||||||||
| WBInteraction000543632 | |||||||||
| WBInteraction000543633 | |||||||||
| WBInteraction000543634 | |||||||||
| WBInteraction000543635 | |||||||||
| WBInteraction000543636 | |||||||||
| WBInteraction000544207 | |||||||||
| WBInteraction000544336 | |||||||||
| WBInteraction000556599 | |||||||||
| WBInteraction000556600 | |||||||||
| WBInteraction000556601 | |||||||||
| WBInteraction000556602 | |||||||||
| WBInteraction000556655 | |||||||||
| WBInteraction000502915 | |||||||||
| Map_info | Map | X | Position | -5.74685 | Error | 0.011682 | |||
| Positive | Positive_clone | F32A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4885 | |||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Sequence connection from [Ahringer JA] | ||||||||
| Sequence connection updated by Darin Blasiar, Feb 2002 | |||||||||
| Gene renamed from ags-3.1 to ags-3 following advice from [Hodgkin J], [020808 krb] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
