WormBase Tree Display for Gene: WBGene00000064
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| WBGene00000064 | SMap | S_parent | Sequence | T04C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | act-2 | Person_evidence | WBPerson259 | |||||
| Sequence_name | T04C12.5 | ||||||||
| Molecular_name | T04C12.5 | ||||||||
| T04C12.5.1 | |||||||||
| CE13150 | |||||||||
| Other_name | act2 | Accession_evidence | EMBL | X16797 | |||||
| CELE_T04C12.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | act-2 | ||||||||
| DB_info | Database | AceView | gene | 5L558 | |||||
| WormQTL | gene | WBGene00000064 | |||||||
| SignaLink | protein | WBGene00000064 | |||||||
| WormFlux | gene | WBGene00000064 | |||||||
| NDB | locus_tag | CELE_T04C12.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000064|UniProtKB=P10984 | |||||||
| family | PTHR11937 | ||||||||
| NCBI | gene | 179534 | |||||||
| RefSeq | protein | NM_001383398.2 | |||||||
| KEGG | KEGG_id | 3.6.4.- | |||||||
| NemaPath | KEGG_id | 3.6.4.- | |||||||
| SwissProt | UniProtAcc | P10984 | |||||||
| UniProt_GCRP | UniProtAcc | P10984 | |||||||
| OMIM | gene | 102560 | |||||||
| 102630 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | act | ||||||||
| Allele (25) | |||||||||
| Strain | WBStrain00031881 | ||||||||
| WBStrain00005465 | |||||||||
| WBStrain00007342 | |||||||||
| WBStrain00007350 | |||||||||
| WBStrain00007351 | |||||||||
| WBStrain00007357 | |||||||||
| WBStrain00007359 | |||||||||
| In_cluster | act-123 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (57) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | act-2 encodes one of five C. elegans actins; act-2 functions redundantly in early embryonic cortical microfilaments with act-1 and act-3, and dominant mutations in act-2 result in uncoordinated locomotion; an ACT-2::GFP reporter fusion is expressed in the cytoplasm of embryonic cells and is also found in contractile filaments in adult muscle cells. | Paper_evidence | WBPaper00001178 | |||||
| WBPaper00001709 | |||||||||
| WBPaper00027028 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||
| DOID:0081113 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||||
| DOID:10881 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||||
| DOID:0081112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||||
| DOID:0110550 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||||
| Molecular_info | Corresponding_CDS | T04C12.5 | |||||||
| Corresponding_transcript | T04C12.5.1 | ||||||||
| Other_sequence (476) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (49) | ||||||||
| Expr_pattern | Expr3813 | ||||||||
| Expr4555 | |||||||||
| Expr1030025 | |||||||||
| Expr1155999 | |||||||||
| Expr2009222 | |||||||||
| Expr2027459 | |||||||||
| Drives_construct | WBCnstr00011672 | ||||||||
| WBCnstr00016094 | |||||||||
| WBCnstr00037759 | |||||||||
| Construct_product | WBCnstr00011672 | ||||||||
| WBCnstr00016094 | |||||||||
| WBCnstr00037759 | |||||||||
| Antibody | WBAntibody00001783 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (206) | |||||||||
| Interaction (415) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | V | Position | 2.94351 | Error | 0.003498 | |||
| Positive | Positive_clone | T04C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 6177 | |||||||
| 6203 | |||||||||
| Multi_point | 4140 | ||||||||
| 4141 | |||||||||
| Reference | WBPaper00000608 | ||||||||
| WBPaper00000611 | |||||||||
| WBPaper00000741 | |||||||||
| WBPaper00000742 | |||||||||
| WBPaper00000785 | |||||||||
| WBPaper00000798 | |||||||||
| WBPaper00000801 | |||||||||
| WBPaper00000969 | |||||||||
| WBPaper00001090 | |||||||||
| WBPaper00001178 | |||||||||
| WBPaper00001230 | |||||||||
| WBPaper00001262 | |||||||||
| WBPaper00001401 | |||||||||
| WBPaper00001542 | |||||||||
| WBPaper00001567 | |||||||||
| WBPaper00001709 | |||||||||
| WBPaper00001895 | |||||||||
| WBPaper00001920 | |||||||||
| WBPaper00002006 | |||||||||
| WBPaper00002305 | |||||||||
| WBPaper00002748 | |||||||||
| WBPaper00004540 | |||||||||
| WBPaper00006387 | |||||||||
| WBPaper00006429 | |||||||||
| WBPaper00014087 | |||||||||
| WBPaper00014311 | |||||||||
| WBPaper00014714 | |||||||||
| WBPaper00016019 | |||||||||
| WBPaper00019693 | |||||||||
| WBPaper00024200 | |||||||||
| WBPaper00024704 | |||||||||
| WBPaper00025088 | |||||||||
| WBPaper00025227 | |||||||||
| WBPaper00027028 | |||||||||
| WBPaper00029197 | |||||||||
| WBPaper00029334 | |||||||||
| WBPaper00030672 | |||||||||
| WBPaper00031353 | |||||||||
| WBPaper00032322 | |||||||||
| WBPaper00033208 | |||||||||
| WBPaper00035956 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038607 | |||||||||
| WBPaper00040301 | |||||||||
| WBPaper00040903 | |||||||||
| WBPaper00044821 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00054920 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057312 | |||||||||
| WBPaper00059214 | |||||||||
| WBPaper00059352 | |||||||||
| WBPaper00059799 | |||||||||
| WBPaper00060410 | |||||||||
| WBPaper00061939 | |||||||||
| WBPaper00062060 | |||||||||
| WBPaper00064107 | |||||||||
| WBPaper00064183 | |||||||||
| WBPaper00065103 | |||||||||
| WBPaper00065156 | |||||||||
| WBPaper00065589 | |||||||||
| WBPaper00066067 | |||||||||
| Remark | M03F4.2 connection removed since latter is on another chromosome. [sdm 0107] | ||||||||
| Sequences T04C12.4 & T04C12.6 removed. email from JAH 0109 | |||||||||
| Method | Gene |
