WormBase Tree Display for Gene: WBGene00000002

WBGene00000002 Evidence: Author_evidence: Veljkovic E
      Verrey F
  SMap: S_parent: Sequence: F27C8
  Identity: Version: 1
    Name: CGC_name: aat-1
      Sequence_name: F27C8.1
      Molecular_name: F27C8.1
        F27C8.1.1
        CE03266
      Other_name: CELE_F27C8.1 Accession_evidence: NDB BX284604
      Public_name: aat-1
    DB_info: Database: AceView gene 4K364
        WormQTL gene WBGene00000002
        WormFlux gene WBGene00000002
        NDB locus_tag CELE_F27C8.1
        Panther gene CAEEL|WormBase=WBGene00000002|UniProtKB=Q19834
          family PTHR11785
        NCBI gene 177793
        RefSeq protein NM_069306.7
        TrEMBL UniProtAcc Q19834
        UniProt_GCRP UniProtAcc Q19834
        OMIM gene 603593
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aat
    Allele (38)
    Strain: WBStrain00054846
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (62)
    Paralog (12)
    Structured_description: Concise_description: aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly. Paper_evidence: WBPaper00006408
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 02 Mar 2006 00:00:00
      Automated_description: Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (26)
  Molecular_info: Corresponding_CDS: F27C8.1
    Corresponding_transcript: F27C8.1.1
    Other_sequence (63)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00087502 Inferred_automatically: RNAi_primary
      WBRNAi00045732 Inferred_automatically: RNAi_primary
      WBRNAi00031488 Inferred_automatically: RNAi_primary
      WBRNAi00113611 Inferred_automatically: RNAi_primary
      WBRNAi00013991 Inferred_automatically: RNAi_primary
      WBRNAi00112392 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1135
      Expr5887
      Expr15194
      Expr1023109
      Expr1030001
      Expr1149639
      Expr2009064
      Expr2027300
    Drives_construct: WBCnstr00003611
      WBCnstr00037804
      WBCnstr00042037
    Construct_product: WBCnstr00037804
      WBCnstr00042037
    Antibody: WBAntibody00000717
    Microarray_results (18)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00029359_1142
      WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:up_in_rde-4
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044246:pgrn-1_ced-3_ced-1_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045861:ash-2(tm1095)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Excretory_gland
      WBPaper00061340:g1A
      WBPaper00061340:g1A_g1P
      WBPaper00061340:g1P
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:M_cell
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm6
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:R07G3.8_9125-ric-4_17408
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:RMH_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:15_0
      WBPaper00065841:27_0
      WBPaper00065841:56_0
      WBPaper00065841:89_0
      WBPaper00065841:146_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00024671:AFD_vs_AWB_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00047070:N2_UV_downregulated
      [cgc6390]:Cluster_B
    Interaction (13)
  Map_info: Map: IV Position: 4.33112 Error: 0.001998
    Positive: Positive_clone: F27C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006408
    WBPaper00024381
    WBPaper00035475
    WBPaper00038491
    WBPaper00042390
    WBPaper00045095
    WBPaper00050950
    WBPaper00053894
    WBPaper00055090
    WBPaper00060013
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene