Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for WBProcess: WBbiopr:00000023

expand all nodes | collapse all nodes | view schema

Name Class

WBbiopr:00000023Public_nameCell migration
SummaryCell movement is an essential cell behavior for metazoan development. When this process is improperly orchestrated it can result in developmental disorders or pathologies such as tumor metastasis. In C. elegans, many cell types including canal associated neurons (CANs), hermaphrodite-specific neurons (HSNs), and Q neuroblasts migrate long distances during embryonic or larval development. Studies in C. elegans have elucidated many of the molecules required for stimulating and guiding the cell. These studies have shown that some directed movement rely on graded chemotactic signaling that is perceived by the cell and transduced to the cell's cytoskeleton. Chemotactic signaling molecules such as UNC-6, an extracellular matrix protein, can act as both an attractant, for cells expressing UNC-5, or as a repellant, for cells expressing UNC-40. Cell migration ultimately requires the regulation of cytoskeletal rearrangements. Studies have demonstrated UNC-73/Trio to be a main activator of Rac signaling in at least some of these migrating cells, which is proposed to drive such intracellular changes.
Related_topicSpecialisation_ofWBbiopr:00000026
Generalisation_ofWBbiopr:00000107
WBbiopr:00000115
Involved_entityGeneWBGene00000416Paper_evidenceWBPaper00004899
WBGene00003029Paper_evidenceWBPaper00027140
WBGene00000858Paper_evidenceWBPaper00027140
WBGene00000419Paper_evidenceWBPaper00004899
WBGene00003006Paper_evidenceWBPaper00027140
WBGene00003397Paper_evidenceWBPaper00027140
WBGene00000478Paper_evidenceWBPaper00027140
WBGene00000424Paper_evidenceWBPaper00004899
WBGene00195122Paper_evidenceWBPaper00027138
WBGene00110038Paper_evidenceWBPaper00027138
WBGene00006805Paper_evidenceWBPaper00005004
WBGene00000426Paper_evidenceWBPaper00004899
WBGene00004773Paper_evidenceWBPaper00027138
WBGene00001185Paper_evidenceWBPaper00027138
WBGene00001188Paper_evidenceWBPaper00027140
WBGene00000857Paper_evidenceWBPaper00027140
WBGene00003395Paper_evidenceWBPaper00027140
InteractionWBInteraction000000779
WBInteraction000000780
WBInteraction000000781
WBInteraction000521001
WBInteraction000521002
WBInteraction000521003
WBInteraction000521004
WBInteraction000521836
WBInteraction000521837
WBInteraction000521838
WBInteraction000521868
WBInteraction000521869
WBInteraction000521870
WBInteraction000521871
WBInteraction000521872
WBInteraction000523881
WBInteraction000523882
WBInteraction000523883
WBInteraction000523884
WBInteraction000523885
WBInteraction000523886
WBInteraction000523887
WBInteraction000523888
WBInteraction000523889
WBInteraction000523890
WBInteraction000523891
WBInteraction000524010
WBInteraction000524011
WBInteraction000524031
WBInteraction000524032
WBInteraction000524033
WBInteraction000524034
WBInteraction000524035
WBInteraction000524197
WBInteraction000524198
WBInteraction000524338
WBInteraction000525095
WBInteraction000525096
WBInteraction000538511
WBInteraction000538512
WBInteraction000538513
WBInteraction000538514
WBInteraction000538515
WBInteraction000538516
WBInteraction000538517
WBInteraction000538518
WBInteraction000538519
WBInteraction000538520
WBInteraction000538521
WBInteraction000538522
WBInteraction000538523
WBInteraction000538524
WBInteraction000538525
WBInteraction000538526
WBInteraction000538527
WBInteraction000538528
WBInteraction000538529
WBInteraction000538530
WBInteraction000538531
WBInteraction000538532
WBInteraction000538533
WBInteraction000538534
WBInteraction000538535
WBInteraction000538536
WBInteraction000538537
WBInteraction000538538
WBInteraction000538539
WBInteraction000538540
WBInteraction000538541
WBInteraction000538543
WBInteraction000538544
WBInteraction000538545
WBInteraction000538546
WBInteraction000538547
WBInteraction000538548
WBInteraction000538549
WBInteraction000538550
WBInteraction000538551
WBInteraction000538552
WBInteraction000538553
WBInteraction000538554
WBInteraction000538555
WBInteraction000538556
WBInteraction000538557
WBInteraction000538558
WBInteraction000538624
WBInteraction000538625
WBInteraction000538626
WBInteraction000538627
WBInteraction000538628
WBInteraction000538637
WBInteraction000538638
WBInteraction000538639
WBInteraction000538640
WBInteraction000538641
WBInteraction000538642
WBInteraction000538643
WBInteraction000538651
WBInteraction000538652
WBInteraction000538653
WBInteraction000538654
WBInteraction000538658
WBInteraction000538659
WBInteraction000538660
WBInteraction000538661
WBInteraction000538662
WBInteraction000538663
WBInteraction000538664
WBInteraction000538665
WBInteraction000538703
WBInteraction000538704
WBInteraction000538705
WBInteraction000538706
WBInteraction000538707
WBInteraction000538708
WBInteraction000538709
WBInteraction000538710
WBInteraction000538711
WBInteraction000538712
WBInteraction000538713
WBInteraction000538714
WBInteraction000538715
WBInteraction000538716
WBInteraction000538717
WBInteraction000538718
WBInteraction000538719
WBInteraction000538720
WBInteraction000538721
WBInteraction000538722
WBInteraction000538723
WBInteraction000538724
WBInteraction000538791
WBInteraction000538845
WBInteraction000538846
WBInteraction000538847
WBInteraction000538848
WBInteraction000540340
WBInteraction000556289
Anatomy_termWBbt:0006830Paper_evidenceWBPaper00027140
WBbt:0008373Paper_evidenceWBPaper00003165
WBPaper00027138
WBbt:0008593Paper_evidenceWBPaper00003818
Associated_withPhenotypeWBPhenotype:0000195
WBPhenotype:0000232
WBPhenotype:0000245
WBPhenotype:0000301
WBPhenotype:0000393
WBPhenotype:0000439
WBPhenotype:0000529
WBPhenotype:0000594
WBPhenotype:0001140
WBPhenotype:0001230
WBPhenotype:0001494
WBPhenotype:0001511
WBPhenotype:0001519
WBPhenotype:0001520
GO_termGO:0016477
ReferenceWBPaper00002582
WBPaper00003165
WBPaper00003627
WBPaper00003818
WBPaper00004899
WBPaper00004959
WBPaper00005004
WBPaper00005417
WBPaper00024939
WBPaper00026706
WBPaper00026842
WBPaper00027138
WBPaper00027140
WBPaper00028783
WBPaper00033059
WBPaper00045025
WBPaper00045431
WBPaper00046000