pgs-1 encodes a phosphatidylglycerophosphate (PGP) synthase; by homology, PGS-1 is predicted to catalyze the formation of phosphatidylglycerophosphate from cytidinediphosphate-diacylglycerol and glycerol 3-phosphate; in C. elegans, pgs-1 activity is required for normal germ cell mitochondrial membrane potential and cristae morphology, as well as for germ cell proliferation.
Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Involved in regulation of cell population proliferation and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrion. Is an ortholog of human PGS1 (phosphatidylglycerophosphate synthase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.