WormBase Tree Display for Gene: WBGene00020649
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| WBGene00020649 | Evidence | Paper_evidence | WBPaper00005858 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T21D12 | ||||||
| Identity | Version | 4 | |||||||
| Name | CGC_name | sma-10 | Paper_evidence | WBPaper00036295 | |||||
| Person_evidence | WBPerson261 | ||||||||
| Sequence_name | T21D12.9 | ||||||||
| Molecular_name | T21D12.9a | ||||||||
| T21D12.9a.1 | |||||||||
| CE28415 | |||||||||
| T21D12.9c | |||||||||
| CE28417 | |||||||||
| T21D12.9a.2 | |||||||||
| T21D12.9c.1 | |||||||||
| Other_name | CELE_T21D12.9 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | sma-10 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jun 2010 15:51:10 | WBPerson2970 | Event | Acquires_merge | WBGene00004863 | ||||
| Name_change | CGC_name | sma-10 | |||||||
| 3 | 13 Jun 2011 13:21:04 | WBPerson1849 | Event | Split_into | WBGene00206487 | ||||
| 4 | 01 Nov 2011 16:31:44 | WBPerson2970 | Event | Acquires_merge | WBGene00004863 | ||||
| Acquires_merge | WBGene00004863 | ||||||||
| Split_into | WBGene00206487 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sma | ||||||||
| Allele (86) | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00003915 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00006593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008977 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00011971 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022789 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | sma-10 encodes a protein containing leucine rich-repeats and immunoglobulin-like domains that is a member of the LRIG family of transmembrane proteins; sma-10 functions to regulate the TGFbeta signaling pathway that controls body size; consistent with genetic epistasis analysis suggesting that SMA-10 acts between the DBL-1/TGFbeta ligand and the SMA-6/TGFbeta receptor in the SMA-6/DAF-4 signaling pathway, SMA-10 physically interacts with both the SMA-6 and DAF-4 TGFbeta receptors in vitro; a SMA-10::GFP translational fusion protein is expressed in the hypodermis and in pharyngeal muscle and is required in the hypodermis for regulating body size. | Paper_evidence | WBPaper00005858 | |||||
| WBPaper00036295 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jun 2010 00:00:00 | ||||||||
| Automated_description | Enables type I transforming growth factor beta receptor binding activity and type II transforming growth factor beta receptor binding activity. Involved in several processes, including positive regulation of transforming growth factor beta receptor signaling pathway; regulation of mesodermal cell fate specification; and transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Human ortholog(s) of this gene implicated in urofacial syndrome. Is an ortholog of human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050816 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20889) | ||||
| Molecular_info | Corresponding_CDS | T21D12.9a | |||||||
| T21D12.9c | |||||||||
| Corresponding_CDS_history | T21D12.9b:wp134 | ||||||||
| T21D12.9b:wp226 | |||||||||
| Corresponding_transcript | T21D12.9a.1 | ||||||||
| T21D12.9a.2 | |||||||||
| T21D12.9c.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf645748 | ||||||||
| WBsf645749 | |||||||||
| WBsf995115 | |||||||||
| WBsf1016530 | |||||||||
| WBsf227825 | |||||||||
| WBsf227826 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00026344 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00018979 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001889 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053735 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027478 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001368 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr6731 | ||||||||
| Expr9899 | |||||||||
| Expr10731 | |||||||||
| Expr13417 | |||||||||
| Expr1014262 | |||||||||
| Expr1038995 | |||||||||
| Expr1157286 | |||||||||
| Expr2015890 | |||||||||
| Expr2034123 | |||||||||
| Drives_construct | WBCnstr00003569 | ||||||||
| WBCnstr00014385 | |||||||||
| WBCnstr00024987 | |||||||||
| Construct_product | WBCnstr00014385 | ||||||||
| WBCnstr00024987 | |||||||||
| WBCnstr00039523 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (16) | |||||||||
| Map_info | Positive | Positive_clone | T21D12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | 2_point | 7144 | |||||||
| 7145 | |||||||||
| 7146 | |||||||||
| Interpolated_map_position | IV | -26.6881 | |||||||
| Reference (24) | |||||||||
| Remark | WBGene00004863 created in error and now merged into this gene. | Curator_confirmed | WBPerson2970 | ||||||
| Method | Gene |
