WormBase Tree Display for Gene: WBGene00016204
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WBGene00016204 | SMap | S_parent | Sequence | C29E4 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | gsto | |||||
Allele (25) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (30) | ||||||
Ortholog (39) | ||||||
Paralog | WBGene00001792 | Caenorhabditis elegans | From_analysis | TreeFam | ||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00015337 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00043097 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00019636 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00001365 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00001371 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00001790 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00001791 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00008920 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00021817 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site. | Paper_evidence | WBPaper00031042 | ||
WBPaper00031083 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 16 Oct 2007 00:00:00 | |||||
Automated_description | Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in cellular response to extracellular stimulus; obsolete oxidation-reduction process; and response to superoxide. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | |
DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23064) | |||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | |||
Molecular_info | Corresponding_CDS | C29E4.7 | ||||
Corresponding_transcript | C29E4.7.1 | |||||
Other_sequence | CBC14472_1 | |||||
AF203814.2 | ||||||
CJC05775_1 | ||||||
Associated_feature | WBsf034318 | |||||
WBsf667116 | ||||||
WBsf227052 | ||||||
Experimental_info | RNAi_result (15) | |||||
Expr_pattern | Expr4883 | |||||
Expr4884 | ||||||
Expr1021261 | ||||||
Expr1036937 | ||||||
Expr1145482 | ||||||
Expr2012336 | ||||||
Expr2030573 | ||||||
Drives_construct | WBCnstr00012309 | |||||
WBCnstr00028246 | ||||||
Construct_product | WBCnstr00012309 | |||||
WBCnstr00028246 | ||||||
Antibody | WBAntibody00001308 | |||||
Microarray_results (18) | ||||||
Expression_cluster (227) | ||||||
Interaction (15) | ||||||
Map_info (3) | ||||||
Reference | WBPaper00024841 | |||||
WBPaper00031042 | ||||||
WBPaper00038491 | ||||||
WBPaper00042271 | ||||||
WBPaper00045842 | ||||||
WBPaper00055090 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |