ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPONENT OF BRANCHED CHAIN KETO ACID DEHYDROGENASE COMPLEX; (DBT), which when mutated leads to maple syrup urine disease, type II (OMIM:248610); the ZK669.4 protein is predicted to be mitochondrial with 68% accuracy.
Predicted to enable acetyltransferase activity and lipoic acid binding activity. Involved in positive regulation of fatty acid biosynthetic process and positive regulation of multicellular organismal process. Located in cilium; cytosol; and neuron projection. Expressed in several structures, including body wall musculature; head neurons; hypodermis; and intestine. Human ortholog(s) of this gene implicated in maple syrup urine disease. Is an ortholog of human DBT (dihydrolipoamide branched chain transacylase E2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.