WormBase Tree Display for Gene: WBGene00007824
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| WBGene00007824 | SMap | S_parent | Sequence | C30H6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dlat-2 | Person_evidence | WBPerson151 | |||||
| Sequence_name | C30H6.7 | ||||||||
| Molecular_name | C30H6.7a | ||||||||
| C30H6.7a.1 | |||||||||
| CE15651 | |||||||||
| C30H6.7b | |||||||||
| Other_name | CELE_C30H6.7 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | dlat-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 29 Nov 2016 11:06:21 | WBPerson2970 | Name_change | CGC_name | dlat-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dlat | ||||||||
| Allele (84) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00034136 | ||||||||
| 00034137 | |||||||||
| 00034138 | |||||||||
| 00034139 | |||||||||
| 00034140 | |||||||||
| 00115857 | |||||||||
| 00115858 | |||||||||
| 00115859 | |||||||||
| Contained_in_operon | CEOP4608 | ||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00009082 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00014054 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020950 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | C30H6.7 encodes a dihydrolipoamide acetyltransferase that is the second enzyme (E2) of the mitochondrial pyruvate dehydrogenase complex; by homology, the product of C30H6.7 is predicted to function in the transfer of an acetyl group to coenzyme A to generate acetyl-CoA for the citric acid cycle. | Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 26 Oct 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be part of mitochondrial pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and sarcoma. Is an ortholog of human PDHX (pyruvate dehydrogenase complex component X). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1115 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21350) | ||||
| DOID:3649 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21350) | ||||||
| Molecular_info | Corresponding_CDS | C30H6.7a | |||||||
| Corresponding_transcript | C30H6.7b | ||||||||
| C30H6.7a.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf646616 | ||||||||
| WBsf008152 | |||||||||
| WBsf229636 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00106956 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00029370 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041580 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011410 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1021601 | ||||||||
| Expr1033393 | |||||||||
| Expr1145604 | |||||||||
| Expr2010940 | |||||||||
| Expr2029179 | |||||||||
| Drives_construct | WBCnstr00033456 | ||||||||
| Construct_product | WBCnstr00033456 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (105) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | IV | Position | 16.6068 | |||||
| Positive | Positive_clone | C30H6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027145 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062388 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
