WormBase Tree Display for Gene: WBGene00014054
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| WBGene00014054 | SMap | S_parent | Sequence | ZK669 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dbt-1 | Paper_evidence | WBPaper00048986 | |||||
| Person_evidence | WBPerson237 | ||||||||
| Sequence_name | ZK669.4 | ||||||||
| Molecular_name | ZK669.4 | ||||||||
| ZK669.4.1 | |||||||||
| CE01115 | |||||||||
| Other_name | CELE_ZK669.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | dbt-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Jan 2016 15:29:00 | WBPerson2970 | Name_change | CGC_name | dbt-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dbt | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00037245 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Contained_in_operon | CEOP2705 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00007824 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00009082 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020950 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPONENT OF BRANCHED CHAIN KETO ACID DEHYDROGENASE COMPLEX; (DBT), which when mutated leads to maple syrup urine disease, type II (OMIM:248610); the ZK669.4 protein is predicted to be mitochondrial with 68% accuracy. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00004637 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable acetyltransferase activity and lipoic acid binding activity. Involved in positive regulation of fatty acid biosynthetic process and positive regulation of multicellular organismal process. Located in cilium; cytosol; and neuron projection. Expressed in several structures, including body wall musculature; head neurons; hypodermis; and intestine. Human ortholog(s) of this gene implicated in maple syrup urine disease. Is an ortholog of human DBT (dihydrolipoamide branched chain transacylase E2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9269 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2698) | ||||
| Molecular_info | Corresponding_CDS | ZK669.4 | |||||||
| Corresponding_transcript | ZK669.4.1 | ||||||||
| Other_sequence (77) | |||||||||
| Associated_feature | WBsf650280 | ||||||||
| WBsf665755 | |||||||||
| WBsf665756 | |||||||||
| WBsf988613 | |||||||||
| WBsf223418 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00112091 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112089 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038407 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112092 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106981 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112090 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059639 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12632 | ||||||||
| Expr12633 | |||||||||
| Expr1010248 | |||||||||
| Expr1036289 | |||||||||
| Expr1163048 | |||||||||
| Expr2010800 | |||||||||
| Expr2029037 | |||||||||
| Drives_construct | WBCnstr00022340 | ||||||||
| WBCnstr00022341 | |||||||||
| WBCnstr00029347 | |||||||||
| Construct_product | WBCnstr00022341 | ||||||||
| WBCnstr00029347 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction (124) | |||||||||
| Map_info | Map | II | Position | 0.618452 | |||||
| Positive | Positive_clone | ZK669 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00042204 | |||||||||
| WBPaper00047693 | |||||||||
| WBPaper00048986 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056557 | |||||||||
| WBPaper00058758 | |||||||||
| WBPaper00060459 | |||||||||
| WBPaper00065140 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
