pafo-1 encodes the C. elegans ortholog of mammalian and Saccharomyces cerevisiae PAF1 that is a member of the PAF1 (Polymerase-Associated Factor 1) complex; by homology PAFO-1 is predicted to function in the regulation of transcription.
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Located in nucleus. Is an ortholog of human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.