WormBase Tree Display for Gene: WBGene00006598
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WBGene00006598 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y37A1B | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | tor | ||||||
Allele (37) | |||||||
Strain | WBStrain00035171 | ||||||
WBStrain00035173 | |||||||
WBStrain00035174 | |||||||
WBStrain00035175 | |||||||
WBStrain00035176 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Contained_in_operon | CEOP4572 | ||||||
Ortholog (34) | |||||||
Paralog | WBGene00003870 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00006597 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA; overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation. | Paper_evidence | WBPaper00005722 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 10 Jan 2008 00:00:00 | ||||||
Automated_description | Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in cellular response to misfolded protein; negative regulation of gene expression; and regulation of neuron apoptotic process. Located in endoplasmic reticulum. Expressed in neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Is an ortholog of human TOR1A (torsin family 1 member A) and TOR1B (torsin family 1 member B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00025083 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 08 Aug 2013 00:00:00 | ||||||
Potential_model | DOID:0080981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | |||
DOID:0060730 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | ||||
Modifies_disease | DOID:543 | ||||||
Models_disease_in_annotation | WBDOannot00000223 | ||||||
Modifies_disease_in_annotation | WBDOannot00000217 | ||||||
Molecular_info | Corresponding_CDS | Y37A1B.13 | |||||
Corresponding_CDS_history | Y37A1B.13:wp243 | ||||||
Corresponding_transcript | Y37A1B.13.1 | ||||||
Associated_feature (2) | |||||||
Experimental_info | RNAi_result | WBRNAi00076763 | Inferred_automatically | RNAi_primary | |||
WBRNAi00055849 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00020200 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00080637 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00036777 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2700 | ||||||
Expr3237 | |||||||
Expr1159380 | |||||||
Expr2017461 | |||||||
Expr2035600 | |||||||
Drives_construct | WBCnstr00000125 | ||||||
WBCnstr00000126 | |||||||
WBCnstr00000127 | |||||||
WBCnstr00000128 | |||||||
WBCnstr00006215 | |||||||
WBCnstr00011243 | |||||||
WBCnstr00034280 | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00000603 | ||||||
WBAntibody00000688 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (79) | |||||||
Interaction (37) | |||||||
WBProcess | WBbiopr:00000078 | ||||||
Map_info | Map | IV | Position | 11.0084 | Error | 0.008317 | |
Positive | Positive_clone | Y37A1B | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (14) | |||||||
Remark | Sequence connection from [Caldwell GA] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |