[Ewbank JJ] toc for similarity to Transporter Of divalent Cations (transporter in operon with clk-1). Predicted gene ZC395.3, SL1 trans-spliced, upstream of clk-1 (ZC395.2)
toc-1 encodes an integral membrane protein with similarity to divalent metal ion transporters; by homology, TOC-1 is predicted to function in regulation of intracellular metal ion (particularly zinc) homeostasis; toc-1 is the upstream gene in an operon with clk-1, a timing gene that is necessary for ubiquinone biosynthesis; RNAi experiments directed against toc-1 sequences result in egg-laying defects, abnormal body coloration, retarded postembryonic growth rates, and generally sick animals.
Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in zinc ion transport. Predicted to be located in Golgi apparatus. Is an ortholog of human SLC30A6 (solute carrier family 30 member 6).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.