acl-3 encodes a glycerol-3-phosphate acyltransferase that is orthologous to human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome); by homology, ACL-3 is predicted to be a mitochondrial protein that plays a role in triacylglycerol metabolism; acl-3 expression shows some degree of dauer-specific induction.
Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and inner mitochondrial membrane organization. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is an ortholog of human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.