smf-1 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-1 plays a minor role in manganese uptake, although mutations in smf-1 do display an increased tolerance to manganese exposure; SMF-1 is broadly expressed fromlate embryogenesis through adulthood, with strongest expression seen in the intestine and its associated gland cells; in epithelia, SMF-1 displays partially overlapping localization at the apical plasma membrane with SMF-3; smf-1 transcription is regulated in response to manganese; when expressed in Saccharomyces cerevisiae, smf-1 can rescue the EGTA hypersensitivity of Smf1+2 mutants.
Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in monoatomic cation homeostasis; negative regulation of cellular response to manganese ion; and response to manganese ion. Located in apical plasma membrane. Expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); leishmaniasis (multiple); and neurodegenerative disease (multiple). Is an ortholog of human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.