WormBase Tree Display for Gene: WBGene00003777
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WBGene00003777 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | nmy-2 | |||||||
Sequence_name | F20G4.3 | ||||||||
Molecular_name | F20G4.3 | ||||||||
F20G4.3.1 | |||||||||
CE27133 | |||||||||
Other_name | CELE_F20G4.3 | Accession_evidence | NDB | BX284601 | |||||
Public_name | nmy-2 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | nmy | ||||||||
Allele (89) | |||||||||
Strain | WBStrain00003254 | ||||||||
WBStrain00024208 | |||||||||
WBStrain00024233 | |||||||||
WBStrain00035727 | |||||||||
WBStrain00040458 | |||||||||
WBStrain00040459 | |||||||||
WBStrain00024223 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (37) | |||||||||
Contained_in_operon | CEOP1432 | ||||||||
Ortholog (45) | |||||||||
Paralog (21) | |||||||||
Structured_description | Concise_description | nmy-2 encodes a non-muscle myosin II; NMY-2 is required for polarized cytoplasmic flow, polarized distribution of the PAR proteins, cytokinesis, and for proper anterior-posterior polarity in early embryos; NMY-2 functions with PAR-5 in the onset of the establishment phase of polarization in the C. elegans zygote along the anterior-posterior axis, and nmy-2 is partially redundant with nmy-1 with respect to embryonic elongation; NMY-2 localization is dynamic in oocytes and embryos, with localization seen at the cell cortex, cleavage furrow, and spindle; once embryonic polarization is established, cortical NMY-2 localizes asymmetrically, with higher levels seen in the anterior cortex; NMY-2 binds bovine calmodulin in vitro in a calcium-dependent manner; during larval development, NMY-2 is required for correct fate specification in seam cell divisions. | Paper_evidence | WBPaper00002506 | |||||
WBPaper00003624 | |||||||||
WBPaper00005318 | |||||||||
WBPaper00005735 | |||||||||
WBPaper00006149 | |||||||||
WBPaper00031011 | |||||||||
WBPaper00036142 | |||||||||
WBPaper00051366 | |||||||||
Person_evidence | WBPerson24060 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 21 Jul 2017 00:00:00 | ||||||||
Automated_description | Enables calmodulin binding activity and protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell division; and regulation of anatomical structure morphogenesis. Located in several cellular components, including cleavage furrow; contractile ring; and mitotic spindle. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neuroblasts; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH10 (myosin heavy chain 10); MYH11 (myosin heavy chain 11); and MYH9 (myosin heavy chain 9). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (13) | ||||||||
Molecular_info | Corresponding_CDS | F20G4.3 | |||||||
Corresponding_CDS_history | F20G4.3:wp47 | ||||||||
Corresponding_transcript | F20G4.3.1 | ||||||||
Other_sequence (26) | |||||||||
Associated_feature (15) | |||||||||
Experimental_info | RNAi_result (38) | ||||||||
Expr_pattern (22) | |||||||||
Drives_construct (11) | |||||||||
Construct_product | WBCnstr00001385 | ||||||||
WBCnstr00005206 | |||||||||
WBCnstr00015078 | |||||||||
WBCnstr00017843 | |||||||||
WBCnstr00038045 | |||||||||
WBCnstr00040019 | |||||||||
Antibody | WBAntibody00000114 | ||||||||
WBAntibody00000929 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (137) | |||||||||
Interaction (212) | |||||||||
WBProcess | WBbiopr:00000017 | ||||||||
WBbiopr:00000073 | |||||||||
Map_info | Map | I | Position | 2.4083 | Error | 0.002722 | |||
Positive | Positive_clone | F20G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4539 | |||||||
4893 | |||||||||
Pseudo_map_position | |||||||||
Reference (148) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |