msh-4 is a partial duplication of the him-14 locus, which encodes the C. elegans MSH4 ortholog; as currently annotated in WormBase, msh-4 can encode a protein nearly identical to HIM-14 residues 631-737, differing only at three amino acids; msh-4(RNAi) results in no apparent defects.
Enriched in Z1.p; Z4.a; germline precursor cell; gon_male_dtc anterior; and gon_male_dtc posterior based on RNA-seq studies. Is affected by several genes including daf-2; sir-2.1; and pgl-1 based on microarray and RNA-seq studies. Is affected by six chemicals including metformin; Sirolimus; and Rifampin based on RNA-seq and microarray studies.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (0.49197)