WormBase Tree Display for Gene: WBGene00002275
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WBGene00002275 | Evidence | Paper_evidence | WBPaper00004339 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | lem-2 | |||||||
Sequence_name | W01G7.5 | ||||||||
Molecular_name | W01G7.5 | ||||||||
W01G7.5.1 | |||||||||
CE20129 | |||||||||
Other_name (3) | |||||||||
Public_name | lem-2 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lem | ||||||||
Allele (91) | |||||||||
Possibly_affected_by | WBVar02153030 | ||||||||
Strain | WBStrain00036509 | ||||||||
WBStrain00003846 | |||||||||
WBStrain00047808 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Contained_in_operon | CEOP2724 | ||||||||
Ortholog (26) | |||||||||
Structured_description | Concise_description | lem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage. | Paper_evidence | WBPaper00005828 | |||||
WBPaper00037942 | |||||||||
WBPaper00040826 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson324 | |||||||||
Date_last_updated | 12 Apr 2012 00:00:00 | ||||||||
Automated_description | Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including microtubule organizing center organization; nuclear membrane reassembly; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00046424 | ||||
Accession_evidence | OMIM | 181350 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 04 Jan 2013 00:00:00 | ||||||||
DOID:0110243 | Homo sapiens | Paper_evidence | WBPaper00059881 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 27 Jun 2020 00:00:00 | ||||||||
Potential_model | DOID:0111536 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28887) | |||||
DOID:0110243 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21244) | ||||||
Disease_relevance | Mutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
Accession_evidence | OMIM | 166700 | |||||||
155950 | |||||||||
16670 | |||||||||
607844 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 06 Mar 2012 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000047 | ||||||||
WBDOannot00000768 | |||||||||
WBDOannot00000769 | |||||||||
WBDOannot00000770 | |||||||||
WBDOannot00000771 | |||||||||
Molecular_info (4) | |||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern | Expr9180 | ||||||||
Expr10879 | |||||||||
Expr11504 | |||||||||
Expr12212 | |||||||||
Expr1014258 | |||||||||
Expr1031341 | |||||||||
Expr1158080 | |||||||||
Expr2013044 | |||||||||
Expr2031276 | |||||||||
Drives_construct | WBCnstr00018933 | ||||||||
WBCnstr00020602 | |||||||||
Construct_product | WBCnstr00001838 | ||||||||
WBCnstr00017548 | |||||||||
WBCnstr00018933 | |||||||||
WBCnstr00020602 | |||||||||
Regulate_expr_cluster | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated | ||||||||
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated | |||||||||
WBPaper00044786:lem-2(tm1582)_downregulated | |||||||||
WBPaper00044786:lem-2(tm1582)_upregulated | |||||||||
Antibody | WBAntibody00000308 | ||||||||
WBAntibody00000309 | |||||||||
WBAntibody00000310 | |||||||||
WBAntibody00000311 | |||||||||
WBAntibody00001855 | |||||||||
WBAntibody00002216 | |||||||||
WBAntibody00002346 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (158) | |||||||||
Interaction (35) | |||||||||
Map_info (4) | |||||||||
Reference (43) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |