cfi-1 encodes a DNA-binding protein containing an AT-rich interaction domain (ARID) that affects differentiation of the URA sensory neurons, AVD, and PVC interneurons; acts downstream of UNC-86 and LIN-32 in controlling URA and IL2 cell fate, and is expressed in some neurons and muscle cells.
Enables sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ganglia; head muscle; neurons; and pharyngeal muscle cell. Is an ortholog of human ARID3B (AT-rich interaction domain 3B).