WormBase Tree Display for Gene: WBGene00013878

WBGene00013878 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: atfs-1 Person_evidence: WBPerson9073
      Sequence_name: ZC376.7
      Molecular_name (15)
      Other_name: CELE_ZC376.7 Accession_evidence: NDB BX284605
      Public_name: atfs-1
    DB_info: Database: AceView gene 5O677
        WormQTL gene WBGene00013878
        WormFlux gene WBGene00013878
        NDB locus_tag CELE_ZC376.7
        Panther gene CAEEL|WormBase=WBGene00013878|UniProtKB=Q23272
          family PTHR13044
        NCBI gene 179922
        RefSeq protein NM_001269642.3
            NM_182360.9
            NM_074114.7
            NM_001029131.6
        SwissProt UniProtAcc Q23272
        TREEFAM TREEFAM_ID TF315772
        UniProt_GCRP UniProtAcc Q23272
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 24 May 2011 10:23:31 WBPerson2970 Name_change: CGC_name: atfs-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atfs
    Allele (102)
    Strain: WBStrain00031161
      WBStrain00031162
      WBStrain00031163
      WBStrain00031164
      WBStrain00037720
      WBStrain00052571
      WBStrain00052572
      WBStrain00052468
    RNASeq_FPKM (74)
    GO_annotation (68)
    Ortholog (23)
    Paralog: WBGene00000221 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007932 Caenorhabditis elegans From_analysis: Panther
      WBGene00012330 Caenorhabditis elegans From_analysis: Panther
      WBGene00077761 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus. Paper_evidence: WBPaper00035985
            WBPaper00041370
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Oct 2012 00:00:00
      Automated_description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:786)
  Molecular_info: Corresponding_CDS: ZC376.7a
      ZC376.7b
      ZC376.7c
      ZC376.7d
    Corresponding_CDS_history: ZC376.7:wp87
    Corresponding_transcript: ZC376.7a.1
      ZC376.7a.2
      ZC376.7b.1
      ZC376.7b.2
      ZC376.7c.1
      ZC376.7c.2
      ZC376.7d.1
    Other_sequence (8)
    Associated_feature (16)
    Gene_product_binds: WBsf980914
    Transcription_factor: WBTranscriptionFactor000444
  Experimental_info: RNAi_result (55)
    Expr_pattern: Expr8935
      Expr9728
      Expr9743
      Expr1015095
      Expr1036209
      Expr1162304
      Expr2009484
      Expr2027721
    Drives_construct: WBCnstr00013629
      WBCnstr00014248
      WBCnstr00014263
      WBCnstr00029481
    Construct_product: WBCnstr00013629
      WBCnstr00021929
      WBCnstr00029481
      WBCnstr00038813
    Regulate_expr_cluster (12)
    Antibody: WBAntibody00002652
    Microarray_results (32)
    Expression_cluster (116)
    Interaction (975)
    WBProcess: WBbiopr:00000077
      WBbiopr:00000079
  Map_info (3)
  Reference: WBPaper00010666
    WBPaper00034543
    WBPaper00035985
    WBPaper00036249
    WBPaper00037396
    WBPaper00041212
    WBPaper00041370
    WBPaper00042171
    WBPaper00043121
    WBPaper00043259
    WBPaper00044964
    WBPaper00045028
    WBPaper00045369
    WBPaper00045829
    WBPaper00046070
    WBPaper00046863
    WBPaper00046902
    WBPaper00047580
    WBPaper00047606
    WBPaper00047707
    WBPaper00047755
    WBPaper00048404
    WBPaper00048445
    WBPaper00048574
    WBPaper00048667
    WBPaper00049307
    WBPaper00049538
    WBPaper00049877
    WBPaper00049898
    WBPaper00050113
    WBPaper00050142
    WBPaper00050412
    WBPaper00050972
    WBPaper00051291
    WBPaper00051378
    WBPaper00051406
    WBPaper00051429
    WBPaper00051631
    WBPaper00051708
    WBPaper00051784
    WBPaper00052708
    WBPaper00053213
    WBPaper00053400
    WBPaper00053677
    WBPaper00053915
    WBPaper00055153
    WBPaper00055941
    WBPaper00056046
    WBPaper00056326
    WBPaper00056418
    WBPaper00057193
    WBPaper00057358
    WBPaper00057378
    WBPaper00057391
    WBPaper00057504
    WBPaper00057508
    WBPaper00057565
    WBPaper00058088
    WBPaper00059352
    WBPaper00059356
    WBPaper00059531
    WBPaper00059545
    WBPaper00059604
    WBPaper00059610
    WBPaper00059627
    WBPaper00059799
    WBPaper00060006
    WBPaper00060073
    WBPaper00060084
    WBPaper00060307
    WBPaper00060501
    WBPaper00060638
    WBPaper00060660
    WBPaper00060692
    WBPaper00060711
    WBPaper00060866
    WBPaper00060909
    WBPaper00060923
    WBPaper00061045
    WBPaper00061067
    WBPaper00061178
    WBPaper00061409
    WBPaper00061526
    WBPaper00061562
    WBPaper00061579
    WBPaper00061628
    WBPaper00061738
    WBPaper00061762
    WBPaper00061852
    WBPaper00061870
    WBPaper00061974
    WBPaper00062237
    WBPaper00062326
    WBPaper00062456
    WBPaper00062467
    WBPaper00062598
    WBPaper00062599
    WBPaper00062625
    WBPaper00062641
    WBPaper00062642
    WBPaper00062750
    WBPaper00062812
    WBPaper00063257
    WBPaper00063389
    WBPaper00063811
    WBPaper00063931
    WBPaper00063971
    WBPaper00063976
    WBPaper00063977
    WBPaper00064082
    WBPaper00064142
    WBPaper00064331
    WBPaper00064403
    WBPaper00064431
    WBPaper00064634
    WBPaper00064637
    WBPaper00064717
    WBPaper00064800
    WBPaper00065565
    WBPaper00065625
    WBPaper00065631
    WBPaper00065768
    WBPaper00065779
    WBPaper00065799
    WBPaper00066042
    WBPaper00066133
    WBPaper00066298
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene