WormBase Tree Display for Gene: WBGene00001145

WBGene00001145 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C16C2
  Identity: Version: 1
    Name: CGC_name: eat-16 Person_evidence: WBPerson32
      Sequence_name: C16C2.2
      Molecular_name: C16C2.2a
        C16C2.2a.1
        CE17404
        C16C2.2b
        CE30491
        C16C2.2b.1
      Other_name: sag-2
        CELE_C16C2.2 Accession_evidence: NDB BX284601
      Public_name: eat-16
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eat
    Allele (53)
    Legacy_information: [Leon Avery] Strong Eat: slippery isthmus and corpus.
      See also ad702
      [C.elegansII] ad702 : strong Eat: slippery isthmus and corpus. [Avery 1993; DA]
    Strain: WBStrain00022805
      WBStrain00023483
      WBStrain00026411
      WBStrain00004787
      WBStrain00005505
      WBStrain00022017
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (38)
    Paralog: WBGene00001179 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004344 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004345 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004347 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004349 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004350 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. Paper_evidence: WBPaper00004713
            WBPaper00004721
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables GTPase activator activity. Involved in several processes, including phospholipase C-inhibiting G protein-coupled receptor signaling pathway; regulation of cell communication; and response to monoamine. Located in cytoplasm; neuron projection; and plasma membrane. Expressed in HSNL; HSNR; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in bradyopsia 1. Is an ortholog of human RGS9 (regulator of G protein signaling 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10004)
  Molecular_info: Corresponding_CDS: C16C2.2a
      C16C2.2b
    Corresponding_CDS_history: C16C2.2:wp77
    Corresponding_transcript: C16C2.2a.1
      C16C2.2b.1
    Other_sequence (34)
    Associated_feature: WBsf643615
      WBsf655796
      WBsf656787
      WBsf218329
      WBsf218330
      WBsf218331
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr1333
      Expr8085
      Expr8866
      Expr8867
      Expr1022292
      Expr1030727
      Expr1144733
      Expr2011152
      Expr2029388
    Drives_construct: WBCnstr00004867
      WBCnstr00005925
      WBCnstr00010225
      WBCnstr00013101
    Construct_product: WBCnstr00004867
      WBCnstr00005925
      WBCnstr00010225
      WBCnstr00013101
    Antibody: WBAntibody00002110
    Microarray_results (33)
    Expression_cluster (105)
    Interaction (54)
    Anatomy_function: WBbtf0195
      WBbtf0990
  Map_info (5)
  Reference: WBPaper00001709
    WBPaper00003591
    WBPaper00003592
    WBPaper00003659
    WBPaper00003880
    WBPaper00004281
    WBPaper00004406
    WBPaper00004502
    WBPaper00004713
    WBPaper00004721
    WBPaper00004854
    WBPaper00005274
    WBPaper00005343
    WBPaper00005615
    WBPaper00010048
    WBPaper00010331
    WBPaper00010466
    WBPaper00010551
    WBPaper00010578
    WBPaper00010588
    WBPaper00010724
    WBPaper00010776
    WBPaper00010864
    WBPaper00011663
    WBPaper00011930
    WBPaper00013467
    WBPaper00015719
    WBPaper00016916
    WBPaper00017110
    WBPaper00017284
    WBPaper00017379
    WBPaper00017471
    WBPaper00017830
    WBPaper00017841
    WBPaper00017852
    WBPaper00017863
    WBPaper00017977
    WBPaper00018268
    WBPaper00018271
    WBPaper00018303
    WBPaper00018927
    WBPaper00019157
    WBPaper00019198
    WBPaper00022884
    WBPaper00023189
    WBPaper00023521
    WBPaper00023538
    WBPaper00023573
    WBPaper00024082
    WBPaper00024096
    WBPaper00024145
    WBPaper00024454
    WBPaper00024526
    WBPaper00024527
    WBPaper00025350
    WBPaper00025475
    WBPaper00026425
    WBPaper00026667
    WBPaper00027044
    WBPaper00027304
    WBPaper00027624
    WBPaper00028134
    WBPaper00028636
    WBPaper00029025
    WBPaper00030189
    WBPaper00030190
    WBPaper00030200
    WBPaper00030406
    WBPaper00031038
    WBPaper00031304
    WBPaper00031681
    WBPaper00031872
    WBPaper00032108
    WBPaper00032706
    WBPaper00032863
    WBPaper00034187
    WBPaper00035489
    WBPaper00036554
    WBPaper00037778
    WBPaper00038117
    WBPaper00038270
    WBPaper00038491
    WBPaper00040144
    WBPaper00041132
    WBPaper00043296
    WBPaper00043510
    WBPaper00043908
    WBPaper00046192
    WBPaper00050796
    WBPaper00051547
    WBPaper00055090
    WBPaper00061021
    WBPaper00064339
    WBPaper00065340
  Remark: Interacting_genes '[Leon Avery] unc-31: Partially suppresses the Unc phenotype of unc-31.
    Sequence From: paul sternberg via ACEDB feedback page <pws@caltech.edu>
    Sequence connection from [Hadju-Cronin YM, Sternberg PS]
    old_name sag-2 becomes new_name eat-16 from [Hadju-Cronin Y, Sternberg PW].
  Method: Gene