a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae.
Predicted to enable DNA-binding transcription factor activity. Involved in cell-cell adhesion and embryo development. Located in cytoplasm and nucleus. Expressed in several structures, including embryonic cell; hypodermis; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Is an ortholog of human HOXB1 (homeobox B1) and HOXD1 (homeobox D1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.