Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006434

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006434EvidenceCGC_data_submission
SMapS_parentSequenceF09E5
IdentityVersion2
NameCGC_nameprdx-2Paper_evidenceWBPaper00006517
Sequence_nameF09E5.15
Molecular_nameF09E5.15a
F09E5.15a.1
CE32361
F09E5.15b
CE41559
F09E5.15c
CE50863
F09E5.15b.1
F09E5.15c.1
Other_nameceprx2Paper_evidenceWBPaper00006517
tag-56CGC_data_submission
CELE_F09E5.15Accession_evidenceNDBBX284602
Public_nameprdx-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
213 Dec 2004 10:52:32WBPerson2970Name_changeCGC_nameprdx-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classprdx
Allele (20)
StrainWBStrain00035650
RNASeq_FPKM (74)
GO_annotation (29)
Contained_in_operonCEOP2172
CEOP2745
Ortholog (43)
ParalogWBGene00011110Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021401Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionprdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants.Paper_evidenceWBPaper00032399
Curator_confirmedWBPerson1843
Date_last_updated10 Dec 2008 00:00:00
Automated_descriptionEnables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:0050715Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9352)
Molecular_infoCorresponding_CDSF09E5.15a
F09E5.15b
F09E5.15c
Corresponding_CDS_historyF09E5.15:wp182
Corresponding_transcriptF09E5.15a.1
F09E5.15b.1
F09E5.15c.1
Other_sequenceAW308627.1
NB07503
BF727637.1
FE914694.1
AW308592.1
EX012167.1
AA294216.1
AI132903.1
PPC01244_1
BF942759.1
GR19342
TS04764
EX565780.1
GRC00075_1
AS03027
ASC22183_1
AA917304.1
BF400312.1
MC03207
AI111271.1
BE132590.1
AW600021.1
ASC01101_1
AA682168.1
ACC26169_1
BMC12241_1
GR17854
TS00402
AI815250.1
AA294390.1
HC01774
MIC00041_1
GRC03655_1
HC02224
ES568619.1
FC813125.1
BG485894.1
AS02846
MPC00226_1
Oden_isotig11079
GPC02310_1
GR977777.1
Acan_isotig22556
NB07483
ES411527.1
AA294452.1
AW874900.1
BG661373.1
Tcol_isotig07781
CGC00895_1
TSC00662_1
CB036746.1
AW313116.1
TX02017
AA736351.1
JI180132.1
EU095848.1
AJ275483.1
OVC03975_2
JI461155.1
AI317893.1
MA03144
AA901469.1
MIC09233_1
OVC03973_1
BG809030.1
BMC02770_1
AA294256.1
BE491911.1
NAC00967_1
BE721011.1
MH01817
PP00536
JI178670.1
AI363565.1
AS00117
AI111199.1
AF105258.1
AA294574.1
AI574567.1
MJC00497_1
BE132533.1
BF118492.1
OVC07599_1
BG310501.1
FE915517.1
GR17886
AA610981.1
OVC09108_1
AI096141.1
CJC12055_1
AW288133.1
BU666303.1
EX562255.1
MI02462
OVC03974_1
BF599216.1
HG09905
DI00483
GE639374.1
EX014597.1
AA294676.1
AI058151.1
AI096040.1
AA680615.1
AW257726.1
BE132531.1
BG310615.1
FE910967.1
GO253104.1
AYC00561_1
AA618768.1
JO473567.1
AA294258.1
JK315586.1
PTC02176_1
JI173439.1
ZP00073
MH01325
BF727536.1
ES741893.1
AYC00040_1
AS14924
HG02212
EX913901.1
AI096316.1
Tcir_isotig09085
PT00896
MH08869
EG025503.1
OOC03451_1
CJC01304_1
CR02463
BF718937.1
BE132618.1
GR17885
AI322135.1
GR13953
Tcol_isotig07782
HC06093
AA618894.1
BF918299.1
AI130640.1
BE095367.1
HBC01869_1
AF004167.1
AI130193.1
BU087196.1
AI096033.1
Hbac_isotig04251
ES570126.1
Tcir_isotig31480
Oden_isotig11077
AI352995.1
AM744368.1
FE909828.1
BF599132.1
MHC06864_1
BMC12455_1
AJ427630.1
H39434.1
BE491856.1
AA670533.1
AA294490.1
AI374033.1
JI210810.1
BE720964.1
FC810988.1
PTC00008_1
BMC12243_1
JO475673.1
AI096114.1
AA934266.1
HGC09404_1
MI00449
AW874883.1
EX008892.1
EL784376.1
OVC02022_1
ES744533.1
AI374046.1
ES672284.1
AW355184.1
AJ133420.1
AJ275483
EH005247.1
JI471549.1
BE209050.1
ASC35734_1
AI130249.1
EX551570.1
DI00288
AAC00526_1
AI096111.1
AA618928.1
JI177317.1
AW453443.1
R95325.1
JI214549.1
EX007794.1
AI436846.1
EX912426.1
JI244833.1
EX916513.1
BF023778.1
Acan_isotig04401
AI096329.1
BE491803.1
AA901419.1
AA680432.1
AI374040.1
BE491855.1
ES409550.1
Dviv_isotig08547
LSC01150_1
BE491931.1
AW208367.1
Dviv_isotig08549
AF068946.1
OVC02146_1
HG10521
BE720949.1
OVC00018_1
AY080902.1
GRC03225_1
BF918241.1
Acan_isotig13567
AS17306
XIC00174_1
BF599171.1
AA523571.1
AS06759
BG310613.1
DN190923.1
AA294097.1
BE209064.1
CRC01457_1
PT00761
AI368347.1
BUC02279_1
AI111200.1
PEC00315_1
AA294412.1
AF001007.1
AW355778.1
AA618882.1
Tcir_isotig24157
HGC00857_1
AI692131.1
EX914979.1
EX559562.1
BF942747.1
AI665728.1
MIC00138_1
MI08807
MI00923
GP02058
PTC03765_1
MI08851
AA618863.1
CD203212.1
TSC02053_1
AI111331.1
MJ02879
DAC01510_1
AA666445.1
XI01176
CGC00228_1
OVC03972_2
FE909241.1
HG03313
AA618802.1
BF400369.1
AA294508.1
BU088792.1
AI373968.1
ES409328.1
FE913591.1
MCC01834_1
AW208369.1
AI055791.1
CJC01279_1
MI02613
CN007690.1
BE238866.1
MAC02213_1
AI111224.1
AA736333.1
JO473552.1
AW453446.1
DIC00271_1
BG485899.1
AA635212.1
BE638384.1
AW409520.1
BF918230.1
AIC00081_1
GU144285.1
BF064291.1
BMC12240_1
AI053000.1
AI132855.1
FC817593.1
BE720970.1
JK315087.1
PSC00992_2
FE916034.1
ES672384.1
GR19341
AI511545.1
AI438754.1
ES672108.1
ACC19427_1
FC811992.1
AI368326.1
AW313111.1
AI438199.1
BMC04808_1
FC812114.1
BF482065.1
FC816455.1
MAC00328_1
AW874887.1
NBC00421_1
AA294529.1
Tcir_isotig10524
SR00321
ZPC00025_1
DA04731
ES740715.1
AA934324.1
AW562105.1
MP00535
DI00096
SC00558
BF400461.1
BMC12244_1
PP00979
Acan_isotig04402
CBC01201_1
AI130345.1
Acan_isotig14316
BE209057.1
AI130100.1
AA618824.1
AW505779.1
AA934270.1
Tcir_isotig22295
EX502356.1
BXC02209_1
AA907975.1
GE638272.1
TDC01337_1
AI444908.1
AW506143.1
LSC01428_1
TCC00451_1
ES672618.1
BF918267.1
FE910795.1
MA00411
GP03085
TX01781
BF482084.1
TSC03888_1
ES570420.1
AI132899.1
JI220301.1
AI130610.1
GW411905.1
FE915626.1
AI095967.1
SRC02711_1
AA294608.1
AE03167
Dviv_isotig35005
AA294448.1
AI205394.1
GO240407.1
BMC12242_1
Name_isotig01907
EX560653.1
OVC03975_1
MH10585
AI130525.1
BE132584.1
FC817723.1
Dviv_isotig08548
GE637892.1
AW288161.1
AI317955.1
TS00204
ACC00567_1
HCC00319_1
BE132614.1
AI096096.1
CR04284
DIC00271_2
PTC04479_1
EX014953.1
AI130326.1
AI317929.1
AJ243736.1
EX014912.1
AA294636.1
ES412410.1
BG809026.1
EX915487.1
EX557286.1
CBC01695_1
BE209022.1
FK670295.1
AW610605.1
GW411548.1
FE919341.1
AW739440.1
AA618840.1
BF599225.1
FC818856.1
BMC15004_1
Oden_isotig11078
MIC09247_1
BF824708.1
HGC00951_1
GE639247.1
AI111222.1
ES672485.1
AA294674.1
GR17855
BF599199.1
AE00970
AI366653.1
FE911699.1
AI095978.1
AS08391
CB886665.1
DVC00233_1
MJ00986
CR02406
MJC02206_1
Tcir_isotig07548
CB037660.1
FE918593.1
BQ804072.1
AE00223
AA736375.1
ES413208.1
ES570370.1
ES562285.1
AI055748.1
MA00260
FE912228.1
EX555696.1
ES560746.1
EX554183.1
ES739983.1
EV850422.1
PE00136
AI130639.1
FE911334.1
HBC12719_1
BE721025.1
HC03544
AI055757.1
PT03501
EX910901.1
Acan_isotig13162
ES561119.1
R95950.1
BF727489.1
BE095346.1
ASC02147_1
AA294564.1
AI130208.1
NBC00421_2
AW257593.1
AW288101.1
ASC00074_1
SRC00934_1
NB07405
AI574588.1
EH005472.1
Dviv_isotig08550
EX011458.1
Associated_feature (15)
Experimental_infoRNAi_result (14)
Expr_patternExpr2948
Expr2949
Expr5699
Expr8393
Expr12198
Expr1024080
Expr1032614
Expr1148092
Expr2015087
Expr2033324
Drives_construct (4)
Construct_productWBCnstr00005484
WBCnstr00011033
WBCnstr00020592
WBCnstr00034358
AntibodyWBAntibody00000736
WBAntibody00001484
Microarray_results (20)
Expression_cluster (165)
Interaction (177)
Anatomy_functionWBbtf0939
WBbtf0940
WBProcessWBbiopr:00000001
WBbiopr:00000055
Map_infoMapIIPosition-1.78616Error0.000241
PositivePositive_cloneF09E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4588
Pseudo_map_position
Reference (38)
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene