WormBase Tree Display for Gene: WBGene00000898
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WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info (12) | |||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Nov 2022 00:00:00 | ||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||
Potential_model (37) | |||||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||
WBPaper00025083 | |||||||
WBPaper00031384 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||
Models_disease_in_annotation | WBDOannot00000339 | ||||||
Models_disease_asserted | WBDOannot00001356 | ||||||
Molecular_info | Corresponding_CDS (6) | ||||||
Corresponding_CDS_history | Y55D5A.5:wp187 | ||||||
Y55D5A.5a:wp229 | |||||||
Y55D5A.5b:wp229 | |||||||
Y55D5A.5b:wp247 | |||||||
Corresponding_transcript | Y55D5A.5b | ||||||
Y55D5A.5a.1 | |||||||
Y55D5A.5c.1 | |||||||
Y55D5A.5d.1 | |||||||
Y55D5A.5e.1 | |||||||
Y55D5A.5f.1 | |||||||
Y55D5A.5g.1 | |||||||
Other_sequence | JI237318.1 | ||||||
JI460661.1 | |||||||
JI460782.1 | |||||||
Dviv_isotig32613 | |||||||
JI225485.1 | |||||||
FG588429.1 | |||||||
TS01021 | |||||||
JI164345.1 | |||||||
GW410969.1 | |||||||
GW410933.1 | |||||||
MCC00359_1 | |||||||
FG586878.1 | |||||||
FC818202.1 | |||||||
FG587857.1 | |||||||
ASC20077_1 | |||||||
AI444866.1 | |||||||
FG586943.1 | |||||||
PP01165 | |||||||
JI213932.1 | |||||||
DW718573.1 | |||||||
FG352215.1 | |||||||
FG347841.1 | |||||||
JI164390.1 | |||||||
TSC01028_1 | |||||||
TSC02510_1 | |||||||
OVC04036_1 | |||||||
MJ00249 | |||||||
TSC10854_1 | |||||||
TSC03411_1 | |||||||
FG586220.1 | |||||||
EX538544.1 | |||||||
AS06201 | |||||||
FG347989.1 | |||||||
JI463509.1 | |||||||
Dviv_isotig27979 | |||||||
TS00523 | |||||||
CV200966.1 | |||||||
JI247992.1 | |||||||
FG351045.1 | |||||||
Dviv_isotig31481 | |||||||
FG349482.1 | |||||||
FG352798.1 | |||||||
TSC09797_1 | |||||||
TS02403 | |||||||
AS17556 | |||||||
MAC02439_1 | |||||||
JI165945.1 | |||||||
FG585129.1 | |||||||
PPC01096_1 | |||||||
JI462906.1 | |||||||
JI463196.1 | |||||||
Dviv_contig33821 | |||||||
FG580350.1 | |||||||
MC01673 | |||||||
FG352161.1 | |||||||
FG351461.1 | |||||||
MC03832 | |||||||
FG580085.1 | |||||||
EX563902.1 | |||||||
TSC01031_1 | |||||||
FG587221.1 | |||||||
MH08265 | |||||||
FG348325.1 | |||||||
Oden_isotig27208 | |||||||
Dviv_isotig22935 | |||||||
JI237473.1 | |||||||
FG353834.1 | |||||||
JI247889.1 | |||||||
FG585478.1 | |||||||
TMC04635_1 | |||||||
FG585066.1 | |||||||
PSC03323_1 | |||||||
BMC08388_1 | |||||||
FG352162.1 | |||||||
TS00880 | |||||||
AS06502 | |||||||
FG585852.1 | |||||||
JI233811.1 | |||||||
JI244268.1 | |||||||
FG582133.1 | |||||||
FG355363.1 | |||||||
ES569665.1 | |||||||
SRC01234_1 | |||||||
TSC07906_1 | |||||||
FG347532.1 | |||||||
DN152658.1 | |||||||
TSC00032_1 | |||||||
ES566643.1 | |||||||
MHC05309_1 | |||||||
ACC14364_1 | |||||||
PSC03250_1 | |||||||
FG584848.1 | |||||||
ES561086.1 | |||||||
JI224031.1 | |||||||
TSC09099_1 | |||||||
EX564073.1 | |||||||
Tcir_isotig30532 | |||||||
FC812547.1 | |||||||
CV198761.1 | |||||||
JI182592.1 | |||||||
FG581255.1 | |||||||
JI248593.1 | |||||||
GP01589 | |||||||
FG588689.1 | |||||||
AS17633 | |||||||
MCC02025_1 | |||||||
CV200947.1 | |||||||
TSC01374_1 | |||||||
TM00309 | |||||||
FG350944.1 | |||||||
JI182489.1 | |||||||
FG349375.1 | |||||||
Associated_feature (24) | |||||||
Experimental_info (11) | |||||||
Map_info | Map | III | Position | -8.03413 | Error | 0.111365 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf11 | |||||
Positive_clone | C44B11 | ||||||
H05C05 | |||||||
Y55D5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Outside_rearr | tDf9 | |||||
Mapping_data | 2_point | 273 | |||||
411 | |||||||
412 | |||||||
7053 | |||||||
Multi_point (23) | |||||||
Pos_neg_data (12) | |||||||
Reference (1726) | |||||||
Picture | WBPicture0000013078 | ||||||
WBPicture0000013087 | |||||||
Method | Gene |