Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006434

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006434EvidenceCGC_data_submission
SMapS_parentSequenceF09E5
IdentityVersion2
NameCGC_nameprdx-2Paper_evidenceWBPaper00006517
Sequence_nameF09E5.15
Molecular_nameF09E5.15a
F09E5.15a.1
CE32361
F09E5.15b
CE41559
F09E5.15c
CE50863
F09E5.15b.1
F09E5.15c.1
Other_nameceprx2Paper_evidenceWBPaper00006517
tag-56CGC_data_submission
CELE_F09E5.15Accession_evidenceNDBBX284602
Public_nameprdx-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
213 Dec 2004 10:52:32WBPerson2970Name_changeCGC_nameprdx-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classprdx
Allele (20)
StrainWBStrain00035650
RNASeq_FPKM (74)
GO_annotation (29)
Contained_in_operonCEOP2172
CEOP2745
Ortholog (43)
ParalogWBGene00011110Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021401Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionprdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants.Paper_evidenceWBPaper00032399
Curator_confirmedWBPerson1843
Date_last_updated10 Dec 2008 00:00:00
Automated_descriptionEnables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:0050715Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9352)
Molecular_infoCorresponding_CDSF09E5.15a
F09E5.15b
F09E5.15c
Corresponding_CDS_historyF09E5.15:wp182
Corresponding_transcriptF09E5.15a.1
F09E5.15b.1
F09E5.15c.1
Other_sequenceAW308627.1
NB07503
BF727637.1
FE914694.1
AW308592.1
EX012167.1
AA294216.1
AI132903.1
PPC01244_1
BF942759.1
GR19342
TS04764
EX565780.1
GRC00075_1
AS03027
ASC22183_1
AA917304.1
BF400312.1
MC03207
AI111271.1
BE132590.1
AW600021.1
ASC01101_1
AA682168.1
ACC26169_1
BMC12241_1
GR17854
TS00402
AI815250.1
AA294390.1
HC01774
MIC00041_1
GRC03655_1
HC02224
ES568619.1
FC813125.1
BG485894.1
AS02846
MPC00226_1
Oden_isotig11079
GPC02310_1
GR977777.1
Acan_isotig22556
NB07483
ES411527.1
AA294452.1
AW874900.1
BG661373.1
Tcol_isotig07781
CGC00895_1
TSC00662_1
CB036746.1
AW313116.1
TX02017
AA736351.1
JI180132.1
EU095848.1
AJ275483.1
OVC03975_2
JI461155.1
AI317893.1
MA03144
AA901469.1
MIC09233_1
OVC03973_1
BG809030.1
BMC02770_1
AA294256.1
BE491911.1
NAC00967_1
BE721011.1
MH01817
PP00536
JI178670.1
AI363565.1
AS00117
AI111199.1
AF105258.1
AA294574.1
AI574567.1
MJC00497_1
BE132533.1
BF118492.1
OVC07599_1
BG310501.1
FE915517.1
GR17886
AA610981.1
OVC09108_1
AI096141.1
CJC12055_1
AW288133.1
BU666303.1
EX562255.1
MI02462
OVC03974_1
BF599216.1
HG09905
DI00483
GE639374.1
EX014597.1
AA294676.1
AI058151.1
AI096040.1
AA680615.1
AW257726.1
BE132531.1
BG310615.1
FE910967.1
GO253104.1
AYC00561_1
AA618768.1
JO473567.1
AA294258.1
JK315586.1
PTC02176_1
JI173439.1
ZP00073
MH01325
BF727536.1
ES741893.1
AYC00040_1
AS14924
HG02212
EX913901.1
AI096316.1
Tcir_isotig09085
PT00896
MH08869
EG025503.1
OOC03451_1
CJC01304_1
CR02463
BF718937.1
BE132618.1
GR17885
AI322135.1
GR13953
Tcol_isotig07782
HC06093
AA618894.1
BF918299.1
AI130640.1
BE095367.1
HBC01869_1
AF004167.1
AI130193.1
BU087196.1
AI096033.1
Hbac_isotig04251
ES570126.1
Tcir_isotig31480
Oden_isotig11077
AI352995.1
AM744368.1
FE909828.1
BF599132.1
MHC06864_1
BMC12455_1
AJ427630.1
H39434.1
BE491856.1
AA670533.1
AA294490.1
AI374033.1
JI210810.1
BE720964.1
FC810988.1
PTC00008_1
BMC12243_1
JO475673.1
AI096114.1
AA934266.1
HGC09404_1
MI00449
AW874883.1
EX008892.1
EL784376.1
OVC02022_1
ES744533.1
AI374046.1
ES672284.1
AW355184.1
AJ133420.1
AJ275483
EH005247.1
JI471549.1
BE209050.1
ASC35734_1
AI130249.1
EX551570.1
DI00288
AAC00526_1
AI096111.1
AA618928.1
JI177317.1
AW453443.1
R95325.1
JI214549.1
EX007794.1
AI436846.1
EX912426.1
JI244833.1
EX916513.1
BF023778.1
Acan_isotig04401
AI096329.1
BE491803.1
AA901419.1
AA680432.1
AI374040.1
BE491855.1
ES409550.1
Dviv_isotig08547
LSC01150_1
BE491931.1
AW208367.1
Dviv_isotig08549
AF068946.1
OVC02146_1
HG10521
BE720949.1
OVC00018_1
AY080902.1
GRC03225_1
BF918241.1
Acan_isotig13567
AS17306
XIC00174_1
BF599171.1
AA523571.1
AS06759
BG310613.1
DN190923.1
AA294097.1
BE209064.1
CRC01457_1
PT00761
AI368347.1
BUC02279_1
AI111200.1
PEC00315_1
AA294412.1
AF001007.1
AW355778.1
AA618882.1
Tcir_isotig24157
HGC00857_1
AI692131.1
EX914979.1
EX559562.1
BF942747.1
AI665728.1
MIC00138_1
MI08807
MI00923
GP02058
PTC03765_1
MI08851
AA618863.1
CD203212.1
TSC02053_1
AI111331.1
MJ02879
DAC01510_1
AA666445.1
XI01176
CGC00228_1
OVC03972_2
FE909241.1
HG03313
AA618802.1
BF400369.1
AA294508.1
BU088792.1
AI373968.1
ES409328.1
FE913591.1
MCC01834_1
AW208369.1
AI055791.1
CJC01279_1
MI02613
CN007690.1
BE238866.1
MAC02213_1
AI111224.1
AA736333.1
JO473552.1
AW453446.1
DIC00271_1
BG485899.1
AA635212.1
BE638384.1
AW409520.1
BF918230.1
AIC00081_1
GU144285.1
BF064291.1
BMC12240_1
AI053000.1
AI132855.1
FC817593.1
BE720970.1
JK315087.1
PSC00992_2
FE916034.1
ES672384.1
GR19341
AI511545.1
AI438754.1
ES672108.1
ACC19427_1
FC811992.1
AI368326.1
AW313111.1
AI438199.1
BMC04808_1
FC812114.1
BF482065.1
FC816455.1
MAC00328_1
AW874887.1
NBC00421_1
AA294529.1
Tcir_isotig10524
SR00321
ZPC00025_1
DA04731
ES740715.1
AA934324.1
AW562105.1
MP00535
DI00096
SC00558
BF400461.1
BMC12244_1
PP00979
Acan_isotig04402
CBC01201_1
AI130345.1
Acan_isotig14316
BE209057.1
AI130100.1
AA618824.1
AW505779.1
AA934270.1
Tcir_isotig22295
EX502356.1
BXC02209_1
AA907975.1
GE638272.1
TDC01337_1
AI444908.1
AW506143.1
LSC01428_1
TCC00451_1
ES672618.1
BF918267.1
FE910795.1
MA00411
GP03085
TX01781
BF482084.1
TSC03888_1
ES570420.1
AI132899.1
JI220301.1
AI130610.1
GW411905.1
FE915626.1
AI095967.1
SRC02711_1
AA294608.1
AE03167
Dviv_isotig35005
AA294448.1
AI205394.1
GO240407.1
BMC12242_1
Name_isotig01907
EX560653.1
OVC03975_1
MH10585
AI130525.1
BE132584.1
FC817723.1
Dviv_isotig08548
GE637892.1
AW288161.1
AI317955.1
TS00204
ACC00567_1
HCC00319_1
BE132614.1
AI096096.1
CR04284
DIC00271_2
PTC04479_1
EX014953.1
AI130326.1
AI317929.1
AJ243736.1
EX014912.1
AA294636.1
ES412410.1
BG809026.1
EX915487.1
EX557286.1
CBC01695_1
BE209022.1
FK670295.1
AW610605.1
GW411548.1
FE919341.1
AW739440.1
AA618840.1
BF599225.1
FC818856.1
BMC15004_1
Oden_isotig11078
MIC09247_1
BF824708.1
HGC00951_1
GE639247.1
AI111222.1
ES672485.1
AA294674.1
GR17855
BF599199.1
AE00970
AI366653.1
FE911699.1
AI095978.1
AS08391
CB886665.1
DVC00233_1
MJ00986
CR02406
MJC02206_1
Tcir_isotig07548
CB037660.1
FE918593.1
BQ804072.1
AE00223
AA736375.1
ES413208.1
ES570370.1
ES562285.1
AI055748.1
MA00260
FE912228.1
EX555696.1
ES560746.1
EX554183.1
ES739983.1
EV850422.1
PE00136
AI130639.1
FE911334.1
HBC12719_1
BE721025.1
HC03544
AI055757.1
PT03501
EX910901.1
Acan_isotig13162
ES561119.1
R95950.1
BF727489.1
BE095346.1
ASC02147_1
AA294564.1
AI130208.1
NBC00421_2
AW257593.1
AW288101.1
ASC00074_1
SRC00934_1
NB07405
AI574588.1
EH005472.1
Dviv_isotig08550
EX011458.1
Associated_feature (15)
Experimental_infoRNAi_result (14)
Expr_patternExpr2948
Expr2949
Expr5699
Expr8393
Expr12198
Expr1024080
Expr1032614
Expr1148092
Expr2015087
Expr2033324
Drives_constructWBCnstr00003077
WBCnstr00011033
WBCnstr00020592
WBCnstr00034358
Construct_productWBCnstr00005484
WBCnstr00011033
WBCnstr00020592
WBCnstr00034358
AntibodyWBAntibody00000736
WBAntibody00001484
Microarray_results (20)
Expression_cluster (165)
Interaction (177)
Anatomy_functionWBbtf0939
WBbtf0940
WBProcessWBbiopr:00000001
WBbiopr:00000055
Map_infoMapIIPosition-1.78616Error0.000241
PositivePositive_cloneF09E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4588
Pseudo_map_position
ReferenceWBPaper00006517
WBPaper00025556
WBPaper00027616
WBPaper00028360
WBPaper00029893
WBPaper00030262
WBPaper00032399
WBPaper00032540
WBPaper00033828
WBPaper00033870
WBPaper00036662
WBPaper00037421
WBPaper00037479
WBPaper00037485
WBPaper00037706
WBPaper00038491
WBPaper00039042
WBPaper00039619
WBPaper00039791
WBPaper00041408
WBPaper00042929
WBPaper00045711
WBPaper00046711
WBPaper00047654
WBPaper00048427
WBPaper00049105
WBPaper00050972
WBPaper00053224
WBPaper00055090
WBPaper00061309
WBPaper00061882
WBPaper00064201
WBPaper00064255
WBPaper00064521
WBPaper00064693
WBPaper00065026
WBPaper00065346
WBPaper00066139
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene