egrh-1 encodes a zinc finger protein that has similarity to the vertebrate EGR (early growth response factor) family of proteins, including the human EGR transcription factors; in C. elegans, EGRH-1 activity is required, non-autonomously in the gut and the somatic gonad, for regulation of oocyte meiotic maturation and ovulation; EGRH-1 is expressed in the somatic gonad, specifically in the gonadal sheath and distal tip cells, and in sperm, as well as in the gut, and other non-gonadal tissues.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of oocyte maturation and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Expressed in body wall musculature; hermaphrodite somatic gonadal cell; nervous system; pharynx; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.