nac-2 encodes a high affinity sodium-coupled citrate transporter that is orthologous to the mammalian citrate transporter NaCT and is one of four C. elegans proteins related to Drosophila Indy; when expressed in a heterologous system, NAC-2 exhibits high affinity sodium/citrate and sodium/succinate cotransporter activity, although the transport rate for citrate is much higher than that for succinate; nac-2::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-2(RNAi) are variable, with reports of a 19% increase in lifespan accompanied by decreased body size and fat content in affected animals and reports of no apparent decrease in average lifespan.
Enables citrate transmembrane transporter activity and succinate transmembrane transporter activity. Involved in several processes, including carboxylic acid transport; determination of adult lifespan; and regulation of growth. Predicted to be located in membrane. Expressed in rect_D; rect_VL; and rect_VR. Is an ortholog of human SLC13A2 (solute carrier family 13 member 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.