exl-1 encodes a putative chloride intracellular channel (CLIC) paralogous to EXC-4; transgenic EXL-1 can partially rescue the exc-4(rh133) mutant phenotype when its expression is driven with an exc-4 promoter; EXL-1 is localized to lysosomes in intestinal cells and coelomocytes, endoplasmic reticulum in coelomocytes, Golgi apparatus in muscle and the neurons PVD and CAN, plasma membrane in muscle arms, and to dense bodies linking muscle cytoskeleton to hypodermis through muscle cell membranes; EXL-1 has an N-terminal PTM domain required for its membrane targeting, and a C-terminal domain resembling omega-type glutathione-S-transferases; EXL-1 has no known function in vivo, and exl-1(ok857) mutants have no obvious phenotype.
Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in apical plasma membrane; cytoplasm; and muscle cell projection membrane. Expressed in coelomocyte; intestine; muscle cell; and neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Is an ortholog of human CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.