WormBase Tree Display for Gene: WBGene00000221

WBGene00000221 SMap: S_parent: Sequence: T04C10
  Identity: Version: 3
    Name: CGC_name: atf-4
      Sequence_name: T04C10.4
      Molecular_name: T04C10.4
        T04C10.4.1
        CE06355
      Other_name: atf-5
        CELE_T04C10.4 Accession_evidence: NDB BX284606
      Public_name: atf-4
    DB_info: Database: AceView gene XP428
        WormQTL gene WBGene00000221
        WormFlux gene WBGene00000221
        NDB locus_tag CELE_T04C10.4
        Panther gene CAEEL|WormBase=WBGene00000221|UniProtKB=Q22156
          family PTHR13044
        NCBI gene 181576
        RefSeq protein NM_001420580.1
        SwissProt UniProtAcc Q22156
        TREEFAM TREEFAM_ID TF318507
        UniProt_GCRP UniProtAcc Q22156
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303075
        3 15 Jul 2019 14:29:07 WBPerson1983 Name_change: CGC_name: atf-4
                Other_name: atf-5
      Split_into: WBGene00303075
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atf
    Allele (54)
    Strain: WBStrain00031503
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog: WBGene00058559 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00029586 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00164338 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      CBOVI.g2842 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g15797 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP38.g20930 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g8765 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00263.g8094 Caenorhabditis angaria From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10034 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00534.g12555 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01702 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_025635 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_X0141500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20647 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00091489 Pristionchus pacificus From_analysis: WormBase-Compara
      FB:FBgn0000370 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
      ZFIN:ZDB-GENE-060526-205 Danio rerio From_analysis: OrthoFinder
            Panther
      ZFIN:ZDB-GENE-030131-2637 Danio rerio From_analysis: OrthoFinder
            Panther
      HGNC:786 Homo sapiens From_analysis: OrthoFinder
            Panther
      HGNC:790 Homo sapiens From_analysis: OrthoFinder
            Panther
      MGI:88096 Mus musculus From_analysis: OrthoFinder
            Panther
      MGI:2141857 Mus musculus From_analysis: OrthoFinder
            Panther
      RGD:621863 Rattus norvegicus From_analysis: OrthoFinder
            Panther
      RGD:628902 Rattus norvegicus From_analysis: OrthoFinder
            Panther
    Paralog: WBGene00012330 Caenorhabditis elegans From_analysis: Panther
      WBGene00007932 Caenorhabditis elegans From_analysis: Panther
      WBGene00013878 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00077761 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4,atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorlytranslated in unstressed cells but well-translated during ER stress, aminoacid starvation, or arsenite treatment; possibly atf-5 is alsotranslationally regulated in a way similar to ATF4. Curator_confirmed: WBPerson567
          Date_last_updated: 09 Aug 2006 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in hydrogen sulfide biosynthetic process and positive regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4) and ATF5 (activating transcription factor 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:786)
  Molecular_info: Corresponding_CDS: T04C10.4
    Corresponding_CDS_history: T04C10.4a:wp264
      T04C10.4b:wp264
    Corresponding_transcript: T04C10.4.1
    Other_sequence (24)
    Associated_feature: WBsf654606
      WBsf978443
      WBsf982291
      WBsf1008012
      WBsf1024465
      WBsf238254
    Transcription_factor: WBTranscriptionFactor000146
  Experimental_info: RNAi_result: WBRNAi00018131 Inferred_automatically: RNAi_primary
      WBRNAi00035130 Inferred_automatically: RNAi_primary
      WBRNAi00000621 Inferred_automatically: RNAi_primary
      WBRNAi00052365 Inferred_automatically: RNAi_primary
      WBRNAi00092892 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11023
      Expr1020406
      Expr1030138
      Expr1155993
      Expr2009480
      Expr2027717
    Drives_construct: WBCnstr00017860
      WBCnstr00037651
    Construct_product: WBCnstr00017860
      WBCnstr00037651
    Regulate_expr_cluster: WBPaper00062518:atf-4_regulated
    Microarray_results (19)
    Expression_cluster (175)
    Interaction (27)
  Map_info: Map: X Position: 21.3687 Error: 0.007883
    Positive: Positive_clone: T04C10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4483
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene